文章摘要
肖淑娜.美罗培南治疗重症肺炎病人对炎症因子和免疫功能的影响[J].实用中西医结合临床,2022,22(10):
美罗培南治疗重症肺炎病人对炎症因子和免疫功能的影响
Effects of Meropenem in Patients with Severe Pneumonia on Inflammatory Factors and Immune Function
投稿时间:2022-04-15  修订日期:2022-05-10
DOI:
中文关键词: 美罗培南  重症肺炎  炎症  T淋巴细胞亚群  免疫球蛋白
英文关键词: Meiluo  Severe pneumonia  Inflammation  T lymphocyte  Immunoglobulin
基金项目:
作者单位E-mail
肖淑娜 河南科技大学第一附属医院 xiaoyuxdada@163.com 
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中文摘要:
      目的 基于机体炎症及免疫功能变化探讨美罗培南(MER)在治疗重症肺炎中的效果。方法 挑选2019年1月到2021年6月在我院治疗的重症肺炎病人105例,按照随机数字表法分为MER组(n=53)和对照组(n=52),对照组采用常规抗炎及支持治疗,MER组在对照组基础上联合MER静滴治疗,比较两组总体疗效、血清感染指标、T淋巴细胞亚群及免疫球蛋白水平差异。结果 治疗后MER组临床总有效率、28d生存率、细菌清除率高于对照组,机械通气时间、住院时间低于对照组(P<0.05);治疗后两组PCT、CRP均降低,且MER组低于对照组(P<0.05);治疗后两组CD3+、CD4+、CD4+/CD8+均升高,CD8+均降低,且MER组变化较对照组更明显(P<0.05);两组IgA、IgG、IgM、C3、C4水平治疗前后、组间对比均无差异(P>0.05)。结论 MER治疗重症肺炎疗效确切,这可能与其提高外周血CD4+T淋巴细胞亚群比例、降低机体炎症反应强度有关。
英文摘要:
      Objective To investigate the effect of meropenem (MER) in the treatment of severe pneumonia based on the changes of inflammation and immune function. Methods A total of 105 patients with severe pneumonia admitted to our hospital from January 2019 to June 2021 were selected and divided into a MER group (n = 53) anda control group (n = 52) according to random number table.The control group was remedied with routine anti-inflammatory and supportive treatment, and the MER group was remedied with MER intravenous drip on the basis of the control group. After treatment, the overall efficacy, serum infection indicators, T lymphocyte and immunoglobulin levels were compared between 2 groups. Results After treatment, the overall response rate, 28-day survival rate and bacterial clearance rate in MER group were higher than control group, while the duration of mechanical ventilation and hospital stay were lower than control group (P < 0.05). After treatment, PCT and CRP in both groups decreased, and MER group was lower than that in control group (P < 0.05). After treatment, CD3 +, CD4 + and CD4 +/CD8 + in both groups increased, CD8 + decreased, and the magnitude in MER group was more obvious than control group (P < 0.05).Before and after treatment,there was no obvious difference in IgA, IgG, IgM, C3 and C4 levels in both groups (P > 0.05). Conclusion MER is effective in the treatment of severe pneumonia, which may be related to its ability to increase the proportion of CD4 + T lymphocytes in peripheral blood and reduce the intensity of the body"s inflammatory response.
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