| 朱杰，储岳峰，周鑫，王庆航，吴浪，张彬.YKL-40、hs-CRP在老年冠心病患者中的临床意义[J].实用中西医结合临床,2021,21(15):1-2,5 |
| YKL-40、hs-CRP在老年冠心病患者中的临床意义 |
| The Clinical Value of YKL-40, hs-CRP in Elderly Patients with Coronary Heart Disease |
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| DOI： |
| 中文关键词: 冠心病 YKL-40 hs-CRP 老年 相关性分析 |
| 英文关键词: Coronary heart disease YKL-40 hs -CRP Elderly Correlation analysis |
| 基金项目:安徽医科大学校科学研究基金资助项目（编号：2020xkj228）；安徽省六安市人民医院科研课题项目（编号：2021kykt22） |
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| 中文摘要: |
| 目的：分析甲壳质酶蛋白40（YKL-40）、高敏C反应蛋白（hs-CRP）在老年冠心病患者中的表达水平及临床意义。方法：选取2019年9月~2020年9月在六安市人民医院心内科就诊的老年患者75例为研究对象。其中急性冠脉综合征（ACS）组25例、稳定型心绞痛（SAP）组25例、非冠心病患者组（对照组）25例，测定各组血清中YKL-40、hs-CRP表达量，比较各组之间表达差异。logistic回归分析筛选冠心病分组中ACS及SAP的危险因素，Pearson直线相关分析研究YKL-40、hs-CRP之间的相关性。结果：YKL-40、hs-CRP在ACS、SAP组中的表达量明显高于对照组，YKL-40、hs-CRP在ACS组中的表达量高于SAP组，差异有统计学差异（P＜0.01）。二分类logistic回归分析结果显示，YKL-40、hs-CRP可能为冠心病的独立危险因素，Pearson直线显示ACS、SAP患者血清YKL-40与hs-CRP含量成正相关（r=0.756，P＜0.01）。结论：YKL-40、hs-CRP可能为冠心病的独立危险因素，ACS、SAP患者血清YKL-40与hs-CRP含量呈正相关，老年冠心病患者血清YKL-40、hs-CRP与疾病严重程度相关。 |
| 英文摘要: |
| Objective: To analyze the expression level and clinical value of YKL-40, hs-CRP in elderly patients with coronary heart disease. Methods: 75 Elderly patients in the department of cardiology of Lu'an people's hospital from September 2019 to September 2020 were selected as the research object. Among them, there were 25 cases in acute coronary syndrome (ACS) group, 25 cases in stable angina pectoris (SAP) group and 25 cases in non-coronary heart disease group (control group). The expressions of YKL-40 and hs-CRP in serum of each group were measured and compared. Logistic regression analysis was used to screen the risk factors of acute coronary syndrome and stable angina pectoris. Pearson linear correlation analysis was used to analyze the correlation between YKL-40 and hs-CRP. Results: The expressions of YKL-40 and hs-CRP in ACS group and SAP group were significantly higher than those in the control group, and the expressions of YKL-40 and hs-CRP in ACS group were higher than those in SAP group, the differences were statistically significant (P＜0.01). Binary logistic regression analysis showed that YKL-40 and hs-CRP may be independent risk factors for coronary heart disease. Pearson straight line showed that there was a positive correlation between serum YKL-40 and hs-CRP in patients with ACS and SAP (r= 0.756, P＜0.01). Conclusion: YKL-40 and hs-CRP may be independent risk factors for coronary heart disease. There is a positive correlation between serum YKL-40 and hs-CRP in patients with ACS and SAP. Serum YKL-40 and hs-CRP are correlated with disease severity in elderly patients with coronary heart disease. |
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