| 邓斌,康书鹏,许镇文.娄氏清痹汤加减配合地塞米松治疗湿热型痛风性关节炎观察[J].实用中西医结合临床,2019,19(8):3-5，52 |
| 娄氏清痹汤加减配合地塞米松治疗湿热型痛风性关节炎观察 |
| Clinical Analysis of LOU's Qingbi Decoction Combined with Dexamethasone in the Treatment of Damp-heat Gouty Arthritis |
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| DOI： |
| 中文关键词: 痛风性关节炎 湿热型 娄氏清痹汤 地塞米松 |
| 英文关键词: Gouty arthritis Damp-heat accumulation type LOU's qingbi decoction Dexamethasone |
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| 中文摘要: |
| 摘要：目的：分析娄氏清痹汤加减配合地塞米松治疗湿热型痛风性关节炎的临床疗效。方法：采用随机数字表法将60例湿热型痛风性关节炎门诊患者分为治疗组和对照组各30例。对照组予地塞米松片、塞来昔布胶囊和秋水仙碱口服治疗，治疗组给予地塞米松片和娄氏清痹汤口服治疗，两组连续治疗7 d，采用11点疼痛程度数字等级量表评分评估两组治疗前后疼痛情况，对比两组疼痛缓解时间，采用关节肿胀评分表评估两组治疗前后关节肿胀情况，检测两组治疗前后血沉、C反应蛋白及血尿酸水平，分析临床疗效。结果：两组治疗后11点疼痛程度数字等级量表评分均较治疗前降低（P＜0.05），但治疗后两组11点疼痛程度数字等级量表评分比较，差异无统计学意义（P＞0.05）。治疗组疼痛缓解时间显著短于对照组（P＜0.05）。治疗组治疗后关节肿胀评分较治疗前显著降低（P＜0.05）；对照组治疗后关节肿胀评分较治疗前降低，但差异无统计学意义（P＞0.05）。治疗组治疗后关节肿胀评分显著低于对照组，差异有统计学意义（P＜0.05）。两组治疗后血沉、C反应蛋白、血尿酸水平均较治疗前降低（P＜0.05），治疗组治疗后血沉、C反应蛋白、血尿酸水平显著低于对照组，差异有统计学意义（P＜0.05）。治疗组总有效率93.33%与对照组的82.76%比较，差异无统计学意义（P＞0.05）。结论：娄氏清痹汤加减配合地塞米松片治疗湿热型痛风性关节炎的临床疗效确切，可缩短患者疼痛缓解时间，减轻患者关节肿胀，降低患者机体血沉、C反应蛋白及血尿酸水平。 |
| 英文摘要: |
| Abstract: Objective: To analyze the clinical effect of LOU's Qingbi decoction combined with dexamethasone in the treatment of damp-heat gouty arthritis. Methods: According to the random number table, 60 outpatients with damp-heat gouty arthritis were divided into the treatment group (n=30) and the control group (n=30). The patients in the control group were given dexamethasone tablets, celecoxib capsules and colchicine, the treatment group were treated with dexamethasone tablets and LOU's Qingbi decoction for 7 days, and the pain level of the two groups before and after treatment were evaluated by pain score scale (NRS-11), and the pain relief time of the two groups was compared. The joint swelling scale was used to evaluate the joint swelling before and after treatment. ESR, CRP and UA were detected and compared before and after treatment in each group, and the clinical curative effect were analyzed. Results: The NRS-11 scores were lower in both groups after treatment than before treatment, there was no significant difference in NRS-11 score between the two groups. The time of pain relief in the treatment group was significantly shorter than that in the control group (P＜0.05). The joint swelling scale in the treatment group was significantly higher than that in the control group (P＜0.05). After treatment, the levels of ESR, CRP and UA in the two groups were significantly lower than before treatment (P＜0.05), and the levels of ESR, CRP and UA in the treatment group were significantly lower than those in the control group (P＜0.05). There was no significant difference in the effective rate between the treatment group(93.33%) and the control group(82.76%) (P＞0.05). Conclusion: LOU's Qingbi decoction combined with dexamethasone is effective in the treatment of damp-heat gouty arthritis, which can achieve the effect of colchicine, desemetone tablet and celecoxib capsule, but the side effects are few, so it is another treatment choice for gout patients. |
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