| 杨淑荣，杨小军，谢强，王雨薇，黄嘉莉.基于外周血EOS-骨髓通路研究谢氏“温督祛霾”针灸法治疗变应性鼻炎的疗效与机制[J].实用中西医结合临床,2019,19(1):1-3,65 |
| 基于外周血EOS-骨髓通路研究谢氏“温督祛霾”针灸法治疗变应性鼻炎的疗效与机制 |
| The Study on the Therapeutic Effect and Mechanism of Xie's "Wenduqumai" Acupuncture and Moxibustion Therapy on Allergic Rhinitis Based on Peripheral Blood EOS-bone Marrow Pathway |
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| DOI： |
| 中文关键词: 变应性鼻炎 针灸疗法 谢氏“温督祛霾” 外周血EOS-骨髓干细胞信号通路 疗效评价 |
| 英文关键词: Allergic rhinitis Acupuncture and moxibustion therapy Xie's "Wenduqumai" Peripheral blood EOS-bone marrow stem cell signaling pathway Therapeutic evaluation |
| 基金项目:江西省科技厅科研项目（编号：20151BBG70126） |
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| 中文摘要: |
| 目的：明确变应性鼻炎（AR）患者是否存在外周血EOS-骨髓干细胞信号通路，评价谢氏“温督祛霾”针灸疗法治疗变应性鼻炎的疗效及对外周血EOS-骨髓干细胞信号通路的影响，为针灸治疗变应性鼻炎提供规范化、科学化操作文本。方法：随机选取我院收治的60例变应性鼻炎患者，采用谢氏“温督祛霾”针灸法治疗，总疗程4周，在治疗2周后及总疗程结束后（4周后）进行疗效评估，于治疗前、总疗程结束后行外周血嗜酸性粒细胞、IL-5细胞因子、CD34+检测。另选择正常成人行外周血嗜酸性粒细胞、IL-5细胞因子、CD34+检测作对照。结果：治疗2周后总有效率为66.67%，治疗4周后总有效率为96.67%；观察组外周血EOS、IL-5和CD34+治疗前与治疗后对比，治疗前与正常对照组对比，均有显著性差异；观察组治疗后EOS值与正常对照组比较有显著性差异，而IL-5、CD34+值与正常对照组比较均无显著性差异。结论：“温督祛霾”针灸疗法治疗变应性鼻炎疗效明显，以4周为较适宜疗程；变应性鼻炎患者存在外周血EOS-骨髓干细胞信号通路；通过检测“温督祛霾”针灸法治疗前后患者外周血EOS-骨髓干细胞通路中相关指标的变化，可初步评价外周血EOS-骨髓通路在AR发病机制中的作用以及“温督祛霾”针灸法对此通路的影响。 |
| 英文摘要: |
| Objective: To determine whether peripheral blood EOS-bone marrow stem cell signaling pathway exists in patients with allergic rhinitis (AR), and to evaluate the effect of Xie's "Wenduqumai" acupuncture and moxibustion therapy on allergic rhinitis and its effect on peripheral blood EOS-bone marrow stem cell signaling pathway, in order to provide a standardized and scientific operating text for the treatment of allergic rhinitis by acupuncture and moxibustion. Methods: 60 Patients with allergic rhinitis were randomly selected to be treated with Xie's "Wenduqumai" acupuncture and moxibustion therapy, the total treatment course was 4 weeks. The therapeutic effect was evaluated after 2 weeks of treatment and 4 weeks after the total course of treatment. Eosinophils, IL-5 cytokines and CD34+ were detected before and after the treatment. In addition, normal adults' peripheral blood eosinophil, IL-5 cytokines and CD34+ were detected as control. Results: After two weeks of treatment, the total effective rate was 66.67%, and the total effective rate was 96.67% after 4 weeks. There were significant differences in EOS, IL-5 and CD34+ before and after treatment in the observation group, and between the observation group and the normal control group before and after treatment. There was significant difference in EOS value between the observation group and the normal control group after treatment, but there was no significant difference in the IL-5, CD34+ value between the observation group and the normal control group. Conclusion: The therapeutic effect of Xie's "Wenduqumai" acupuncture and moxibustion therapy on allergic rhinitis is obvious, with 4 weeks as the most suitable course, and there is a signal pathway of bone marrow stem cells in peripheral blood in patients with allergic rhinitis. To detect the changes of the related indexes in peripheral blood EOS-bone marrow stem cell pathway of patients before and after the “Wenduqumai” acupuncture and moxibustion therapy, can preliminarily evaluated the role of peripheral blood EOS-bone marrow pathway in pathogenesis of AR and the effect of “Wenduqumai” acupuncture and moxibustion therapy on this pathway. |
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