复方片仔癀肝宝对乙醇代谢的影响

林珊; 陈达鑫; 赵锦燕; 曾建伟; 洪振丰

文章摘要

林珊陈达鑫赵锦燕曾建伟洪振丰.复方片仔癀肝宝对乙醇代谢的影响[J].实用中西医结合临床,2016,16(11):1-3

复方片仔癀肝宝对乙醇代谢的影响

Effects of Complex Prescription Pianzaihuang Ganbao on Alcohol Metabolism

DOI：

中文关键词: 复方片仔癀肝宝乙醇代谢顶空气质联用仪

英文关键词: Complex prescription Pianzaihuang Ganbao Alcohol metabolism Headspace gas chromatography-mass spectrometry

基金项目:2013年度陈可冀中西医结合发展基金（编号：CJK2013015）；福建省教育厅A类科技项目（编号：JA14163）

作者	单位
林珊陈达鑫赵锦燕曾建伟洪振丰	福建中医药大学中西医结合研究院；福建省中西医结合老年性疾病重点实验室

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中文摘要:

目的：探讨复方片仔癀肝宝对乙醇代谢的影响。方法：SD雄性大鼠随机分为正常对照组、模型组、海王金樽组（阳性对照）和复方片仔癀肝宝高、中、低剂量组，每组8只。给药后0.5 h除了正常对照组，其余各组灌胃白酒。采用顶空气质联用法（HS-GC-MS）测定给酒后0.5、1、2、3、5 h大鼠血液中的乙醇浓度，运用ELISA法检测乙醇达到峰值时乙醇脱氢酶和乙醛脱氢酶的含量。结果：复方片仔癀肝宝组在不同时间点大鼠血液中的乙醇、乙醇脱氢酶和乙醛脱氢酶的浓度均低于模型组（P＜0.05）。结论：复方片仔癀肝宝促进乙醇代谢，达到解酒的目的。

英文摘要:

Objective: To observed the anti-alcoholism effect of complex prescription Pianzaihuang Ganbao (GB). Methods: Male SD rats were divided into six groups randomly as follows: control group, model group, GB low dose group, GB middle dose group, GB high dose group and Haiwangjinzun group (HWJZ, as positive control). After oral medication, the rats were orally administration with alcohol, except for the rats in the control group. Blood was collected after 0.5, 1, 2, 3, 5 hours drinking alcohol separately. The content of alcohol in blood were determined by HS-GC-MS, the content of ethanol dehydrogenase and acetaldehyde dehydrogenase were determined by ELISA. Results: The content of alcohol, ethanol dehydrogenase and acetaldehyde dehydrogenase in blood of the GB groups were decreased (P＜0.05). Concusion: The GB can promote the metabolism of alcohol to accelerate the climination of ethanol.

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