| 易路遥 熊蔚.高效液相色谱法测定马来酸多潘立酮片的含量[J].实用中西医结合临床,2016,16(10):77-79 |
| 高效液相色谱法测定马来酸多潘立酮片的含量 |
| High Performance Liquid Chromatography Method for Determining the Content of Domperidone Maleate Tablets |
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| DOI： |
| 中文关键词: 马来酸多潘立酮片 含量测定 高效液相色谱法 |
| 英文关键词: Domperidone maleate tablets Determination of content HPLC |
| 基金项目: |
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| 中文摘要: |
| 目的：建立了高效液相色谱法测定马来酸多潘立酮片含量的方法。方法：使用十八烷基硅烷键合硅胶为填充剂的色谱柱，流动相为甲醇-0.5%乙酸铵（55﹕45），检测波长为285 nm，流速1 ml/min，柱温30 ℃。结果：马来酸多潘立酮在0.129 4~5.176 ?滋g呈良好线性关系，相关系数r2为0.999 99；加标回收率98.21%~101.73%。结论：本法准确、可靠，可用于马来酸多潘立酮片的质量控制。 |
| 英文摘要: |
| Objective: To establish a method to determinate the content of domperidone maleate tablets by high performance liquid chromatography (HPLC). Methods: Using C18 column, the mobile phase was methanol-0.5% ammonium acetate (55:45), the detection wavelength was 285 nm, the flow rate was 1.0 ml/min, the temperature of column was set at 30 ℃. Results: Domperidone maleate in 0.129 4~5.176 ?滋g showed a good linear relationship, the correlation coefficient r2 was 0.999 99, the rate of recovery was 98.21%~101.73% of standard addition. Conclusion: This method is accurate and reliable, can be used for the quality control of domperidone maleate tablets. |
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