王小青 王剑 赵诗云 吴东风 刘丹.穿心莲内酯对小鼠早期感染性休克的影响[J].实用中西医结合临床,2016,16(8):76-78 |
穿心莲内酯对小鼠早期感染性休克的影响 |
Effect of Andrographolide on Mice of Early Septic Shock |
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DOI: |
中文关键词: 穿心莲内酯 小鼠 感染性休克模型 内毒素 |
英文关键词: Andrographolide Mice Model of septic shock LPS |
基金项目:江西省卫生计生委中医药科研课题(编号:2014A006) |
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中文摘要: |
目的:建立感染性休克小鼠动物模型后,观察穿心莲内酯对早期感染性休克小鼠的影响。方法:采用小鼠腹腔注射内毒素(LPS)造成感染性休克模型,观察穿心莲内酯对模型小鼠的影响。结果:穿心莲内酯能明显改善感染性休克小鼠的肠道水肿,同时可以降低肺、肾、肝脏器损害程度。结论:穿心莲内酯对LPS建立的小鼠感染性休克具有保护作用。 |
英文摘要: |
Objective: Establishing mice model of septic shock, to observe the effect of andrographolide on early septic shock. Methods: The mice model with septic shock caused by intraperitoneal injection of lipopolysaccharide (LPS), to observe the effect of andrographolide on early septic shock. Results: Andrographolide could significantly improve intestinal edema, and reduce lung, kidney, hepatic lesion degree of mice model with septic shock. Conclusion: Andrographolide has protective effect of mice with septic shock caused LPS. |
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