| 赵汝勤.阿奇霉素联合山莨菪碱治疗小儿支原体肺炎的临床疗效及对免疫功能的影响[J].实用中西医结合临床,2016,16(8):5-6,11 |
| 阿奇霉素联合山莨菪碱治疗小儿支原体肺炎的临床疗效及对免疫功能的影响 |
| The Therapeutic Effects and Immune Function of Azithromycin Combined with Anisodamine in Treatment of Mycoplasma Pneumonia in Children |
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| DOI： |
| 中文关键词: 小儿支原体肺炎 免疫功能 阿奇霉素 山莨菪碱 临床疗效 |
| 英文关键词: Mycoplasma pneumonia Immune function Azithromycin Anisodamine Clinical curative effect |
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| 中文摘要: |
| 目的：探讨阿奇霉素联合山莨菪碱治疗小儿支原体肺炎的临床疗效及其对免疫功能的影响。方法：选取2014年5月~2016年4月我院收治的小儿支原体肺炎患儿共140例。随机分为观察组和对照组，每组70例，两组患者均予以化痰、止咳及对症支持治疗，同时予以阿奇霉素10 mg/（kg·d）静滴7 d。观察组在此基础上加用山莨菪碱注射液肺腧穴注射0.1~0.2 mg/（kg·d），持续治疗7 d。对比两组患儿临床症状消失时间及住院时间、治疗前和治疗14 d后的血浆免疫球蛋白和细胞炎症因子。结果：观察组的咳嗽缓解时间、退热时间、肺部罗音消失时间和住院天数显著低于对照组（P＜0.05）。两组患儿治疗后的中性粒细胞百分比、血沉及CRP显著低于治疗前（P＜0.05）；观察组治疗后的中性粒细胞百分比、血沉及CRP显著低于对照组（P＜0.05）。经过治疗后，观察组患儿的血浆IgA、IgG、IgM较治疗前显著升高（P＜0.05），且观察组和对照组之间有显著统计学差异（P＜0.05）。结论：阿奇霉素联合山莨菪碱治疗小儿支原体肺炎可有效缩短病程，降低炎症反应，改善免疫功能，临床疗效可靠。 |
| 英文摘要: |
| Objective: To explore the therapeutic effects and immune function of Azithromycin combined with Anisodamine in treatment of mycoplasma pneumonia in children. Methods: 140 Children with mycoplasma pneumoniaour who were treated in our hospital from May 2014 to April 2016 were selected and randomly divided into observation group and control group. Patients were to be removing phlegm,stopping cough and symptomatic and supportive treatment, and were given azithromycin 10 mg/(kg·d), infusion 7 d. On this basis, the observation group was received lung acupoint injection of Anisodamine 0.1~0.2 mg/(kg·d), 7 d. The clinical symptoms and hospitalization time, the plasma immunoglobulin and inflammatory cytokines before and after treatment were compared in two groups. Results: The cough relief time, cooling time, pulmonary rales disappeared time and days of hospitalization in the observation group was significantly lower than the control group (P＜0.05). The percentage of neutrophils, ESR and CRP in two groups after treatment were significantly lower than before treatment (P＜0.05). The percentage of neutrophils, ESR and CRP in the observation group after treatment was significantly lower than the control group (P＜0.05). After treatment, the plasma levels of IgA, IgG and IgM of the observation group were significantly higher than before treatment (P＜0.05), and there was significant difference between the observation group and the control group (P＜0.05). Conclusion: Azithromycin combined with Anisodamine treatment of mycoplasma pneumonia in children can be effective to shorten the course, reduce inflammation, improve immune function, and reliable clinical efficacy. |
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