| 周策 唐太春 余乐来 龙浩然 黄德铨.自拟真人养脏汤治疗脾肾阳虚型溃疡性结肠炎的临床观察[J].实用中西医结合临床,2015,15(10):1-3,42 |
| 自拟真人养脏汤治疗脾肾阳虚型溃疡性结肠炎的临床观察 |
| Clinical Observation on Therapeutic Effect and Adverse Event of Self-prescribed Zhenrenyangzang Decoction for Spleen and Kidney Yang Deficiency Type Ulcerative Colitis |
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| DOI： |
| 中文关键词: 溃疡性结肠炎 中医药疗法 脾肾阳虚 真人养脏汤 |
| 英文关键词: Ulcerative colitis (UC) TCM Therapy Spleen and Kidney yang Deficiency Zhenrenyangzang decoction (ZD) |
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| 中文摘要: |
| 目的：观察自拟真人养脏汤治疗脾肾阳虚型溃疡性结肠炎的临床效果及不良反应，并与美沙拉嗪进行疗效比较。方法：将确诊的87例脾肾阳虚型溃疡性结肠炎患者随机分为治疗组43例与对照组44例，治疗组以自拟真人养脏汤加减治疗，对照组用美沙拉嗪治疗，疗程均为6周，比较两组患者的临床疗效及复发率。结果：治疗后两组患者在腹泻、黏液脓血便、腹痛、形寒肢冷、里急后重等症状以及综合疗效方面比较，治疗组均优于对照组，差异有统计学意义（P＜0.01或P＜0.05）。3个月内治疗组复发率（27.03%）与对照组（35.48%）的差异无统计学意义。结论：自拟真人养脏汤在治疗脾肾阳虚型溃疡性结肠炎方面疗效确切且安全，与美沙拉嗪治疗比较，在改善患者腹泻、黏液脓血便、腹痛、形寒肢冷、里急后重等症状更有优势，在防止复发方面差异不明显。 |
| 英文摘要: |
| Objective: To observe therapeutic effect and adverse event of self-prescribed Zhenrenyangzang decoction (ZD) for spleen and kidney yang deficiency type UC as in comparison with Masalasine. Methods: 87 Patients diagnosed with UC were randomly divided into two groups, 43 in treatment group and 44 in control group. Patients in the treatment group were given modified ZD while patients in the control group were treated with Masalazine. Treatment for both groups lasted for 6 weeks, the clinical effect and recurrence rate were observed and analyzed. Results: After treatment, the comprehensive effect, including alleviation of symptoms, such as diarrhea, bloody purulent stool with mucus, abdominal pain, cold sensation in body and extremities and tenesmus, witnessed improvement compared with that of control group, with statistical significance (P＜0.01 or P＜0.05). There was no statistical significance between treatment group (27.03%) and control group (35.48%) regarding recurrence rate within 3 months. Conclusion: Self-prescribed ZD has therapeutic effect and is safe for spleen and kidney yang deficiency type UC. Compared with Masalasine, it has better clinical effect on alleviation of symptoms like diarrhea, bloody purulent stool with mucus, abdominal pain, cold sensation in body and extremities and tenesmus. There is no significant difference between Self-prescribed ZD and Masalazine in recurrence prevention. |
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