| 王茂华 段晓霞 刘雪茹.参附注射液对食管癌根治术单肺通气后炎症反应的影响[J].实用中西医结合临床,2014,14(12):3-4，6 |
| 参附注射液对食管癌根治术单肺通气后炎症反应的影响 |
| Effects of Shenfu Injection on Inflammatory Response After Esophagectomy |
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| DOI： |
| 中文关键词: 参附注射液 食道癌根治术 单肺通气 炎性反应 |
| 英文关键词: Shenfu injection Esophagectomy One lung ventilation Inflammation |
| 基金项目:四川省教育厅科研基金（编号：14ZB0151）;四川省泸州市科技局科研基金（编号：2014S45） |
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| 中文摘要: |
| 目的：探讨参附注射液对食道癌根治术所致肺损伤的保护作用。方法：60例限期行食道癌根治术患者，随机分为参附注射液组（n=30）和对照组（n=30）。于麻醉诱导后参附注射液组按1 mL/kg静脉给予参附注射液，对照组给予等容量的生理盐水。于单肺通气开始时（T0）、单肺通气1 h（T1）、恢复双肺通气3 h时（T2）各监测时间点抽取动脉血5 mL，用酶联免疫吸附法（ELISA）法测定血浆中白介素6（IL-6）、白介素8（IL-8）和肿瘤坏死因子?琢（TNF-?琢）的浓度。结果：两组患者T1、T2时点的血浆IL-6、IL-8和TNF-?琢的水平均较T0明显升高（P<0.05）。参附注射液组在T2时点的血浆IL-6、IL-8水平以及T1、T2时点的血浆TNF-?琢水平均明显低于对照组（P<0.05）。结论：参附注射液减轻了食道癌根治术单肺通气期间及其后血浆炎症因子IL-6、IL-8和TNF-?琢的水平，减轻了炎症反应。 |
| 英文摘要: |
| Objective: To investigate the clinical effects of Shenfu injection (SF) on inflammatory response after esophagectomy. Methods: 60 Patients ready for esophagectomy were divided into two groups randomly, each group consisting of 30 cases. In Shenfu injection (SF) group, patients were given 1 mL/kg Shenfu injection after anesthesia induction. In control group, patients were given normal saline of equal volume after anesthesia induction. Plasma IL-6, IL-8 and TNF-?琢 levels were measured at baseline (T0), 1 h after one lung ventilation (T1) and 3 h after lung reinflation (T2). Results: Compared with baseline level, plasma IL-6, IL-8 and TNF-?琢 levels at T1, T2 point were both increased (P<0.05). Compared with the control group, patients in SF group had reduced plasma IL-6, and IL-8 level at T2 point, and reduced TNF-?琢 at both T1 and T2 point (P<0.05). Conclusion: Shenfu injection can reduce plasma IL-6, IL-8 and TNF-?琢 levels after esophagectomy while minimizing inflammation. |
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