王茂华 段晓霞 刘雪茹.参附注射液对食管癌根治术单肺通气后炎症反应的影响[J].实用中西医结合临床,2014,14(12):3-4,6 |
参附注射液对食管癌根治术单肺通气后炎症反应的影响 |
Effects of Shenfu Injection on Inflammatory Response After Esophagectomy |
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DOI: |
中文关键词: 参附注射液 食道癌根治术 单肺通气 炎性反应 |
英文关键词: Shenfu injection Esophagectomy One lung ventilation Inflammation |
基金项目:四川省教育厅科研基金(编号:14ZB0151);四川省泸州市科技局科研基金(编号:2014S45) |
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中文摘要: |
目的:探讨参附注射液对食道癌根治术所致肺损伤的保护作用。方法:60例限期行食道癌根治术患者,随机分为参附注射液组(n=30)和对照组(n=30)。于麻醉诱导后参附注射液组按1 mL/kg静脉给予参附注射液,对照组给予等容量的生理盐水。于单肺通气开始时(T0)、单肺通气1 h(T1)、恢复双肺通气3 h时(T2)各监测时间点抽取动脉血5 mL,用酶联免疫吸附法(ELISA)法测定血浆中白介素6(IL-6)、白介素8(IL-8)和肿瘤坏死因子?琢(TNF-?琢)的浓度。结果:两组患者T1、T2时点的血浆IL-6、IL-8和TNF-?琢的水平均较T0明显升高(P<0.05)。参附注射液组在T2时点的血浆IL-6、IL-8水平以及T1、T2时点的血浆TNF-?琢水平均明显低于对照组(P<0.05)。结论:参附注射液减轻了食道癌根治术单肺通气期间及其后血浆炎症因子IL-6、IL-8和TNF-?琢的水平,减轻了炎症反应。 |
英文摘要: |
Objective: To investigate the clinical effects of Shenfu injection (SF) on inflammatory response after esophagectomy. Methods: 60 Patients ready for esophagectomy were divided into two groups randomly, each group consisting of 30 cases. In Shenfu injection (SF) group, patients were given 1 mL/kg Shenfu injection after anesthesia induction. In control group, patients were given normal saline of equal volume after anesthesia induction. Plasma IL-6, IL-8 and TNF-?琢 levels were measured at baseline (T0), 1 h after one lung ventilation (T1) and 3 h after lung reinflation (T2). Results: Compared with baseline level, plasma IL-6, IL-8 and TNF-?琢 levels at T1, T2 point were both increased (P<0.05). Compared with the control group, patients in SF group had reduced plasma IL-6, and IL-8 level at T2 point, and reduced TNF-?琢 at both T1 and T2 point (P<0.05). Conclusion: Shenfu injection can reduce plasma IL-6, IL-8 and TNF-?琢 levels after esophagectomy while minimizing inflammation. |
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