| 吴德强.和厚朴酚脂质体的制备及表征[J].实用中西医结合临床,2014,14(8):86-88 |
| 和厚朴酚脂质体的制备及表征 |
| The Preparation and Characterization of Honokiol Liposome |
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| DOI： |
| 中文关键词: 和厚朴酚 脂质体 正交设计 缓释制剂 |
| 英文关键词: Honokiol Liposome Orthogonal design Sustained-release preparation |
| 基金项目: |
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| 摘要点击次数: 538 |
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| 中文摘要: |
| 目的：为了提高和厚朴酚的稳定性和溶解性，增强其肿瘤靶向性，制备和厚朴酚脂质体并对其进行表征。方法：采用薄膜水化-挤出法制备和厚朴酚脂质体，通过超滤法测定包封率，以包封率为指标优化和厚朴酚脂质体的制备工艺和处方因素，通过粒径分布和体外释放对其进行表征。结果：优化工艺和处方为磷脂与药物的重量比为60∶1，磷脂与胆固醇的重量比为20∶1，水化介质为pH 6.5磷酸盐缓冲液，超声时间为6 min。所得到的和厚朴酚脂质体平均粒径为150 nm，96 h体外累积释药量为55.2%。结论：优化工艺所制备的和厚朴酚脂质体包封率高，工艺稳定，基本达到了缓释控释及靶向制剂的设计要求。 |
| 英文摘要: |
| Objective: Preparing and charactering Honokiol liposome; to improve the stability, solubility and tumor-targeting effect of Honokiol. Methods: Honokiol liposome was prepared by the film hydration extrude method. The encapsulate efficiency was determined by ultrafiltration and the optimum formation was selected by means of orthogonal design of experiment followed charactering the distribution of particle size and Honokiol in vitro release behavior. Results: The optimum formula was as follows: the ratio of lecithin to drug was 60:1; lecithin: cholesterol was 20:1; pH of PBS was 6.5, ultrasonic time was 6 min. The average particle size was 150 nm and the cumulative release of Honokiol at 96 h was 55.2%. Conclusion: The encapsulate efficiency of Honokiol liposome is high and achieve the requirement of controlling release and target formula. |
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