| 胡耀明 付银银.IL-18与原发性高血压左室肥厚的相关性研究[J].实用中西医结合临床,2012,(6):7-8 |
| IL-18与原发性高血压左室肥厚的相关性研究 |
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| DOI： |
| 中文关键词: 高血压 左心室肥厚 IL-18 |
| 英文关键词: Essential hypertension Left ventricular hypertrophy Interleukin-18 |
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| 中文摘要: |
| 目的：探讨白细胞介素-18(IL-18)与原发性高血压左心室肥厚(LVH)的关系，以及IL-18在高血压左心室肥厚发病中的作用机制。方法：60例原发性高血压患者及30名健康者均行彩色超声心动图检查并计算左心室质量指数(LVM I)，用ELISA法测定血清IL-18水平。结果：高血压组3个不同分级组血清IL-18水平均明显高于对照组（P <0.05）；高血压组3个不同分级组间血清IL-18水平差异有统计学意义（P <0.05）；高血压左心室肥厚组IL-18水平明显高于无左心室肥厚组（P <0.05），且与心肌肥厚指数成显著正相关（?酌= 0. 52,P <0.05）。结论：IL-18可能参与了原发性高血压的病理生理过程及左心室肥厚的形成。 |
| 英文摘要: |
| Objective:To investigate the relationship of levels of serum Interleukin-18(IL-18) with essential hypertension ( EH) and left ventricular hypertrophy(LVH) in patients.Methods:The value of left ventricular mass of 30 normal individuals and 60 patients with EH were evaluated by Doppler echocardiography.The serum levels of IL-18 were measured by ELISA method.Results:The serum levels of IL-18 in patients with EH were significantly higher than that in normal individuals（P <0.05）.There were significant difference in the levels of IL-18 among the 3 clinical grading of EH（P <0.05）.The levels of IL-18 were higher in LVH group than that in NLVH group（P <0.05）;and their levels had positive correlation with LVMI（?酌= 0.52,P <0.05）.Conclusion:IL-18 is probably involved in the pathophysiological process of essential hypertension and acts as important role in the occurrence and development of LVH. |
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