| 马彬 胡耀明.sCD40L与急性冠脉综合征的相关性研究[J].实用中西医结合临床,2011,(4):69-70 |
| sCD40L与急性冠脉综合征的相关性研究 |
|
| |
| DOI： |
| 中文关键词: 可溶性CD40配体 急性冠状动脉综合征 动脉粥样硬化 |
| 英文关键词: Soluble CD40L Acute coronary syndrome Arteriosclerosis |
| 基金项目: |
|
| 摘要点击次数: 612 |
| 全文下载次数: 265 |
| 中文摘要: |
| 目的：研究血清sCD40L水平与冠状动脉粥样硬化严重程度是否相关。方法：对不稳定型心绞痛(UA)患者进行Braunwald分级，对急性心肌梗死(AMI)患者心脏功能进行Killip分级，对冠状动脉粥样硬化病变程度按照病变支数按Gensini评分进行量化评估，用酶联免疫吸附法检测血清sCD40L水平；用SPSS13.0软件包进行统计学分析。结果：急性冠脉综合征（ACS）组sCD40L水平高于正常对照组及稳定型心绞痛组（P <0.01）；AMI组sCD40L水平高于UA组（P <0.05）。冠状动脉三支及双支病变组SCD40L水平高于单支病变组（P <0.05）；ACS组sCD40L水平与冠状动脉病变数量呈Pearson正相关(r=0.216，P =0.002)；sCD40L与Gensini评分呈正相关（r= 0.321，P =0.001）。结论：sCD40L水平可能是急性冠状动脉综合征临床识别和预测疾病严重程度的炎症指标。 |
| 英文摘要: |
| Objective:To evaluate whether the changes of serum sCD40L in patients with acute coronary syndrome(ACS) correlated with severity of the diseases.Methods:Patients with UA were separated into 3 groups by Braunwald asses and those with AMI were separated into 4 groups by Killip classes.The coronary artery lesions score was recorded according to single，double and triple vessel lesions and Gensini scoring system. The concentrations of serum sCD40L were measured by enzyme linked immunoabsorbent assay.Data was estimated by SPSS13.0.Result:The level of sCD40L were obviously higher in the ACS group than in the control group（P <0.01）and in the SA group（P<0.01）;The level sCD40L were higher in multi- vessel coronary artery lesions group than in single-vessel group（P< 0.05）;The marker were positively correlated with the numbers of vessels lesions(r=0.216，P =0.002) and the Gensini score (r =0.321，P = 0.001) respectively. Conclusion:The level of sCD40L may be used as marker to diagnosis and evaluate the severity of this disease. |
|
查看全文
查看/发表评论 下载PDF阅读器 |
| 关闭 |
