| 孙运萍.大承气汤对重症急性胰腺炎细胞因子TNF-α、IL-6、IL-8、PAF的影响[J].实用中西医结合临床,2009,(1):1-4 |
| 大承气汤对重症急性胰腺炎细胞因子TNF-α、IL-6、IL-8、PAF的影响 |
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| DOI： |
| 中文关键词: 急性重症胰腺炎 细胞因子 ELISA法 大承气汤 |
| 英文关键词: Acute severe pancreatitis Cytokines ELISA Dachengqi decoction |
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| 摘要点击次数: 674 |
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| 中文摘要: |
| 目的：探讨病程早期应用大承气汤治疗重症急性胰腺炎（SAP）对患者细胞因子TNF-α、IL-6、IL-8、PAF水平的影响及对腹痛消失时间、腹胀消失时间、上腹压痛消失时间、恢复进食时间等临床表现及化验结果等方面的影响。方法：选取急性重症胰腺炎病人32例，随机分为两组，16例为实验组，16例为对照组。实验组除常规治疗方法外，加用大承气汤方剂胃管内注入。采用ELISA双抗体夹心法分别测定两组患者血中细胞因子在治疗前及治疗后3d、5d各时相点的含量，比较治疗前后细胞因子的下降程度。观察比较两组患者腹痛消失时间、腹胀消失时间、上腹压痛消失时间、恢复进食时间、各种化验指标及病情转归。采用SPSS统计软件做数据处理。结果：入院时两组患者细胞因子TNF-α、IL-6、IL-8、PAF的含量均升高，两组比较无明显区别，差异无统计学意义（P >0.05）。实验组治疗3d后，TNF-α、IL-6、IL-8、PAF含量均有所下降，分别为(32.8±6.1)pg/mL、(26.8±6.7)pg/mL、(42.3±4.2)pg/mL、(4.30±0.93)pg/mL；实验组治疗5d后，各细胞因子含量较治疗3d后又进一步下降，数值分别为(18.6±7.8)pg/mL、(16.4±7.2)pg/mL、(25.6±3.9)pg/mL、(2.30±0.83)pg/mL。实验组治疗3d和治疗5d后，各细胞因子均有所下降，且下降幅度较对照组明显，差异有统计学意义(P <0.05)。实验组腹痛消失时间、腹胀消失时间、上腹压痛消失时间、恢复进食时间均较对照组缩短，白细胞恢复正常时间、血尿淀粉酶恢复时间、CRP恢复正常时间均较对照组短，差异有统计学意义(P <0.05)。结论：早期使用中药方剂大承气汤治疗重症胰腺炎可通过降低细胞因子含量，防止肠道功能衰竭而改善其预后。 |
| 英文摘要: |
| Objectives:To evaluate the effect of cytokines TNF-?琢,IL-6,IL-8 and PAF in applying with Dachengqi Decoction in the early stage to treat SAP. And to clinical performance and chemical examination results, and so on. Methods: 32 SAP patients were randomly divided into two groups, control group 16 and examination group 16. Examination group in addition to regular treaty methods, also apply with Dachengqi Decoction. Apply with ELISA to test each group IL-6, IL-8, TNF-α and PAF in blood before and after treating 3d and 5d respectively. Compare the level of reducing cytokines before and after the treating 3d and 5d. Observe and compare the time of the two groups abdominal pain disappearing, abdominal distension disappearing time, abdominal tenderness disappearing time and the time of restoring to eat food. By biochemistry method, amylase and urine-amylase were tested to show the time which take for them to restore to normal. Leukocyte, C reaction protein restoring time. Compare the rate of complication, rate of changing to surgical operation, mortality, average time of being hospitalized, average spending in hospital and prognostic of the disease. Dispose of the data with SPSS statistic soft.Results:After therapy for 3 days and 5 days to experimental group, cytokines were reduced more significantly than control group. The comparison of the two groups, clinical symptom and sign were significant. Conclusion: the early application of herbal prescription Dachengqi decoction could reduce the levels of TNF-α, IL-6, IL-8 and PAF, has an obviously protective effect on intestinal barrier function and improve the prognosis of SAP. |
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