| 赵玲 卢富华 指导：黄春林.糖毒清对糖尿病肾病大鼠肾组织VCAM-1表达影响的研究[J].实用中西医结合临床,2006,(1):1-2 |
| 糖毒清对糖尿病肾病大鼠肾组织VCAM-1表达影响的研究 |
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| DOI： |
| 中文关键词: 糖尿病肾病 肾功能不全 VCAM-1 糖毒清 实验研究 益气助阳 化瘀泄浊 |
| 英文关键词: Diabetic Renal Insufficiency VCAM-1 Tangduqing empirical study removing blood stasis and resolving masses supplementing qi and aiding yang |
| 基金项目:广东省科技厅(2002C30502)及广东省教育厅(Z02010)资助项目 |
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| 中文摘要: |
| 目的：探讨糖毒清治疗糖尿病肾病肾功能不全的可能机制。方法：采用5/6肾切除合中等剂量的STZ腹腔注射方法建立糖尿病肾病肾功能不全模型，将造模成功的大鼠50只随机分为5组：模型组（生理盐水2mL/d灌胃）、糖毒清高剂量组[糖毒清6.75g/（kg·d）灌胃]；糖毒清中剂量组[糖毒清4.5g/（kg·d）灌胃]、糖毒清低剂量组[糖毒清2.25g/（kg·d）灌胃]、尿毒清组[尿毒清2.25g/（ kg·d）灌胃]。另外10只正常对照组大鼠予生理盐水2mL/d灌胃；治疗10周后，通过免疫组化的方法检测各组大鼠肾组织的VCAM-1表达情况。结果：模型组大鼠肾组织VCAM-1表达明显增多，而糖毒清组大鼠肾组织VCAM-1的表达明显减少。结论： 糖毒清可以减少糖尿病肾病肾功能不全大鼠肾组织VCAM-1的过度表达,从而达到控制或延缓糖尿病肾病肾功能恶化的进程。 |
| 英文摘要: |
| Objective： To clarify the possible mechanisms of Tangduqing granules through examining and comparing the expressions of VCAM-1 in renal tissues of model rats with diabetic renal insufficiency (DRI). Methods: Sixty male SD rats were experienced combination of 5/6 nephrectomy and abdominal cavity injection with midium-dose streptozotocin to establish model rats with DRI. Fifty successful model rats with DRI were divided into five groups randomly: Model Group (Administered with NS 2mL/d).High Dose Group [Administered with Tangduqing 6.75g/（kg·d)]、Medium Dose Group [Administered with Tangduqing 4.5g/（kg·d)]、Low Dose Group [Administered with Tangduqing 2.25g/（kg·d)]、 Niaoduqing Group [Administered with Niaoduqing 2.25g/（kg·d)]. Ten age-matched healthy male SD rats were served as controls(Administered with NS 2mL/d). Ten weeks later, the expressions of VCAM-1 in renal tissues of rats with DRI were observed through immunohistochemical method.Results: The expressions of VCAM-1 in renal tissues of rats with DRI were obviously enhanced. The expressions of VCAM-1 in renal tissues of rats with Tangduqing were obviously decreased。Conclusion :Tangduqing might reduce the over-expression of VCAM-1 in renal tissues of rats with DRI, and control or delay the development of renal failure. |
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