| 苏开鑫 林智 王宏芬 谢华 唐道鹤.红芪水提液防治大鼠类固醇性骨质疏松的实验研究[J].实用中西医结合临床,2005,(4):4-5 |
| 红芪水提液防治大鼠类固醇性骨质疏松的实验研究 |
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| DOI： |
| 中文关键词: 红芪 水提液 醋酸泼尼松 骨质疏松 实验研究 |
| 英文关键词: Radix Hedysari Prednisone acetate Osteoporosis experimental study |
| 基金项目: |
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| 摘要点击次数: 571 |
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| 中文摘要: |
| 目的： 探讨红芪水提液对糖皮质激素性骨质疏松大鼠的防治作用。方法：30只3月龄清洁级雄性SD大鼠，随机分为3组即对照组、模型组、实验组。对照组用生理盐水灌胃，模型组用醋酸泼尼松灌胃，实验组用红芪水提液灌胃。每周称体重1次，于第13周处死，测量胫骨上段松质骨的骨形态计量学指标。结果：模型组大鼠的体重较对照组减轻显著，骨形成减少，骨吸收增加，骨量减少；实验组与模型组比较，体重增加，骨形成增加，骨吸收减少，骨量增加，接近对照组的水平。结论：红芪水提液能防治醋酸泼尼松引起的骨质疏松症。 |
| 英文摘要: |
| Objective: To study the effect of Radix Hedysari in preventing the glucocortcoid-induced osteoporosis in rats. Methods: Thirty male Spague-Dawley rats at 3 month of age were divided into 3 groups : control group, model group, experiment group. The control group was given normal aaline ; the model group was given prednisone acetate;the experiment group was given prednisone acetate and Radix Hedysari. All rats were weighed once a week. In the 13th week, all rats in each group were killed, The histomorphometric parameters of the proximal tibia were measured. Results: Compared with the control group, s, the weight of the model group， s was inclined, bone formation was decreased, the bone resorption was increased; But, as compared with the model group, s, the treat group，s weight was increased, bone formation was increased, the bone resorption was decreased significantly. Conclusion: Radix Hedysari could prevent the osteoporosis which caused by prednisone acetate. |
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