| 杜敏 周华英 李惠军.甘油果糖注射液中氯化钠的含量测定研究[J].实用中西医结合临床,2005,(2):69-71 |
| 甘油果糖注射液中氯化钠的含量测定研究 |
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| DOI： |
| 中文关键词: 甘油果糖注射液 氯化钠 含量测定 滴定分析法 |
| 英文关键词: Glycerol and Fructose Injection Sodium Chloride Determination of the Contents titrimetric analysis |
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| 中文摘要: |
| 目的：对甘油果糖注射液中氯化钠含量进行测定。方法：采用国家药品标准的高效液相色谱以及美国药典滴定分析法方法测定甘油果糖注射液中氯化钠的含量。结果：表明氯化钠在色谱系统中有较长时间的保留平衡过程；同时果糖产生的杂质与氯化钠的色谱保留时间一致，影响氯化钠的测定。结论：改用滴定分析法测定注射液中的氯化钠，方法简便，专属性强，结果准确、可靠，精密度良好、回收率高。 |
| 英文摘要: |
| Objective:To determination of the contents of Sodium Chloride in the Glycerol and Fructose Injection .Methods:Determination of the contents of Sodium Chloride with HPLC and titrimetirc analysis.Result:It is showed that the balance process of Sodium Chloride in the column is long. Further more, the retention time of the impurity from Fructose is overlap with which of Sodium Chloride, which will effect the determination of the Contents of Sodium Chloride in the Glycerol and Fructose Injection.Conclusion:It is simply to determine the contents of Sodium Chloride use the titrimetric analysis with silver nitrate titrant, and the method is satisfaction, the RSD% is less than 1%, and the average recovery is 99.88%. |
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