| 万小明 肖锐 孙小波 余南征 王丽华.丹参液配合同种异体冻干骨移植治疗激素性股骨头坏死机理研究[J].实用中西医结合临床,2004,(6):1-3 |
| 丹参液配合同种异体冻干骨移植治疗激素性股骨头坏死机理研究 |
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| DOI： |
| 中文关键词: 激素性股骨头坏死 丹参液 同种异体冻干骨移植 中西医结合疗法 GANFH |
| 英文关键词: Glucocorticoid-Induced Avascular Necrosis of Femoral Head Silvia Miltiorrhiza Concrete Injection Homogeneous Allograft Bone GANFH |
| 基金项目:江西省自然科学基金资助项目（编号；0240013） |
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| 中文摘要: |
| 目的：观察丹参液配合同种异体冻干骨移植治疗激素性股骨头坏死的机理。方法:制作NCW兔激素性股骨头坏死模型,每组右侧股骨头行丹参及同种异体冻干骨移植术，全部左侧仅行入路手术以作对比，手术实验后2月、3月分别处死一半动物取股骨头行肉眼观察、组织学观察及透射电镜观察。结果：丹参、同种异体冻干骨的植入一方面起到钻孔减压的效果，改善股骨头的微循环，降低静脉压，有利于重建血运，毛细血管的再生；另一方面既可充当支架，有利于毛细血管在其多孔网状的内壁爬行生长，又可作为新骨沉积的基质。结论：以上是丹参配同种异体冻干骨移植治疗激素性股骨头坏死作用机理。 |
| 英文摘要: |
| Objective:To discuss the Silvia Miltiorrhiza Concrete Injection and Homogeneous Allograft Bone with Deeply Refrigeneous-Preserved on Treatment of the Glucocorticoid-Induced Avascular Necrosis of Femoral Head (GANFH). Methods:After the models of GANFH of rabbits are finished successfully by administering horse serum and much steroid,thirty-six NCW rabbits were devided into two groups randomly. The right femoral heads of each group were conducted with silvia miltiorrhiza concrete injection and homogeneous allograft bone with deeply refrigeneous-preserved respectively. All left femoral head only were conducted with approach and exposure of femoral heads and necks. Killing the half of animals after operation 2 and 3 months late, we had observed the femoral head about outward appearance,photoscope and electroscope.Result:It could improve the circulation of femoral head, have the function of increasing trabeculace growth and support the appearance of femoral heads. We had observed vessel growing, enlarged marrow fat cells, trabeculace becoming thinner and sparse, empty osteocytes lacuna in the trabeculace being elevated.Conclusion:All the result indicated that the silvia miltiorrhiza concrete injection and homogeneous allograft bone with deeply refrigeneous-preserved progress the Treatment of the GANFH. |
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