冠状动脉慢血流患者血栓弹力图特点分析

吴章明; 熊尚全; 李翠云; 吴翔

文章摘要

吴章明，熊尚全，李翠云，吴翔.冠状动脉慢血流患者血栓弹力图特点分析[J].实用中西医结合临床,2022,22(5):7-11

冠状动脉慢血流患者血栓弹力图特点分析

Analysis of the Characteristics of Thromboelastography in Patients with Coronary Slow Flow

DOI：

中文关键词: 冠状动脉慢血流血栓弹力图冠脉TIMI血流帧数

英文关键词: Coronary slow flow Thromboelastography Coronary TIMI blood flow frame number

基金项目:福建省自然科学基金项目（编号：2018J01330）

作者	单位
吴章明，熊尚全，李翠云，吴翔	福建中医药大学附属人民医院

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中文摘要:

目的：分析冠状动脉慢血流患者血栓弹力图的特点，观察其与冠脉TIMI血流帧数的相关性。方法：回顾性分析2019年1月至2021年11月于福建中医药大学附属人民医院心血管内科因胸闷、胸痛初次就诊患者2 426例临床资料。根据入选标准，最终纳入冠状动脉慢血流患者50例为观察组，经冠脉造影检查排除冠心病且无冠脉慢血流患者50例为对照组。收集两组的一般资料、血栓弹力图、血脂、纤维蛋白原、血小板数据，观察组冠脉TIMI血流帧数等资料，进行统计学分析。结果：观察组吸烟人数（18例）明显多于（6例）对照组，差异有统计学意义（P＜0.05）。两组纤维蛋白原、血小板水平比较，差异无统计学意义（P＞0.05）。观察组血栓弹力图R、K明显较对照组低，α角、MA较对照组升高，差异有统计学意义（P＜0.05）。观察组冠脉平均TIMI血流帧数与血栓弹力图的R、K、α角、MA均无明显相关性（P＞0.05）。结论：吸烟患者更容易引起冠状动脉慢血流。有冠状动脉慢血流的患者血液系统呈高凝血因子活性，纤维蛋白原及血小板功能明显增高，处于高血栓风险状态。

英文摘要:

Objective: To analyze the characteristics of thromboelastography in patients with coronary slow flow, and to observe its correlation with coronary TIMI blood flow frame number. Method: We analyzed retrospectively the data of 2 426 patients who were initially admitted to the Department of Cardiovascular Medicine, People's Hospital Affiliated to Fujian University of Traditional Chinese Medicine due to chest tightness and chest pain from January 2019 to November 2021. According to the inclusion criteria, 50 patients with coronary slow blood flow were finally included in the observation group, and 50 patients without coronary heart disease excluded by coronary angiography and without coronary slow flow were included in the control group. The general data, thromboelastography, blood lipids, fibrinogen, platelets of the two groups, and coronary TIMI blood flow frame number in the observation group were collected for statistical analysis. Results: The number of smokers in the observation group (18 cases) was significantly higher than that in the control group (6 cases), and the difference was statistically significant (P＜0.05). There was no significant difference in fibrinogen and platelet levels between the two groups (P＞0.05). The R and K of the observation group were significantly lower than those of the control group, and the α angle and MA of the observation group were higher than those of the control group, the difference was statistically significant (P＜0.05). There was no significant correlation between the mean coronary TIMI blood flow frame number and the R, K, α angle and MA of thrombelastography (P＞0.05). Conclusion: Smoking patients are more likely to cause coronary slow flow. Patients with coronary slow flow show high coagulation factor activity, fibrinogen and platelet function increas significantly, and are in a state of high thrombosis risk.

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