| 王璐，周佳林，戴琦.基于数据挖掘探讨腹泻型肠易激综合征（肝郁脾虚型）用药规律[J].实用中西医结合临床,2022,22(1):95-99,106 |
| 基于数据挖掘探讨腹泻型肠易激综合征（肝郁脾虚型）用药规律 |
| Research on Medication Law of Diarrhea-predominant Irritable Bowel Syndrome (Liver Depression and Spleen Deficiency Type) Based on Data Mining |
| |
| DOI： |
| 中文关键词: 腹泻型肠易激综合征 肝郁脾虚型 数据挖掘 中药治疗 用药规律 |
| 英文关键词: Diarrhea-predominant irritable bowel syndrome Liver depression and spleen deficiency type Data mining Traditional Chinese Medicine treatment Medication law |
| 基金项目: |
|
| 摘要点击次数: 368 |
| 全文下载次数: 99 |
| 中文摘要: |
| 目的：以数据挖掘为基础探讨腹泻型（肝郁脾虚型）肠易激综合征（IBS-D）治疗的核心药对和潜在配伍规律，以期为今后的临床治疗及理论研究提供参考。方法：收集文献数据库中从建库至2020年12月所有关于肝郁脾虚型IBS-D的相关文献，提取相关方药信息后运用相关软件进行频数分析、关联规则分析、聚类分析。结果：共纳入704篇文献，228味药物，中药归经以脾经为主，药性以温为主，药味以甘为主，补虚药用之最多；前8位高频药物为白术、白芍、陈皮、防风、茯苓、柴胡、党参、甘草；关联规则分析示白术、陈皮、防风、白芍有强关联性；聚类分析分为6类，分别为方剂痛泻要方、参苓白术散、柴胡疏肝散、半夏泻心汤加减及活血行气类、温中涩肠类。结论：数据挖掘研究为今后IBS-D的理论、临床研究提供了依据；肝郁脾虚型IBS-D临床上多用痛泻要方加减治疗，且多秉持柔肝健脾、温中涩肠原则，并结合临床实际情况进行辨证论治。 |
| 英文摘要: |
| Objective: Based on data mining, this paper discusses the core drug pairs and potential compatibility rules in the treatment of diarrhea-predominant (liver depression and spleen deficiency type) irritable bowel syndrome (IBS-D), in order to provide reference for clinical treatment and theoretical research in the future. Methods: All relevant literatures on IBS-D of liver depression and spleen deficiency type from the establishment of the literature database to December 2020 were collected, extracted the relevant prescription information, and used relevant software for frequency analysis, association rule analysis and cluster analysis. Results: A total of 704 literatures and 228 medicines were included. The meridians of Traditional Chinese Medicine were mainly spleen meridians, the medicinal properties were mainly warm, the medicinal flavor was mainly sweet, and the medicine for tonifying deficiency was the most; the top 8 high-frequency drugs were Atractylodes macrocephala, Radix Paeoniae Alba, tangerine peel, Fangfeng, Poria cocos, bupleurum, dangshen and licorice; the analysis of association rules showed that Atractylodes macrocephala, tangerine peel, Fangfeng and Radix Paeoniae Alba had strong correlation; cluster analysis was divided into 6 categories: Tongxie yaofang, Shenling baizhu powder, Chaihu shugan powder, modified Banxia xiexin decoction, promoting blood circulation and Qi, warming middle and astringent intestines. Conclusion: The research of data mining provides a basis for the theoretical and clinical research of IBS-D in the future; IBS-D of liver depression and spleen deficiency type is treated by adding and subtracting Tongxieyaofang, and mostly adheres to the principle of softening the liver and strengthening the spleen, warming the middle and astringent intestines, and carries out syndrome differentiation and treatment in combination with the actual clinical situation. |
|
查看全文
查看/发表评论 下载PDF阅读器 |
| 关闭 |
|
|
|
