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| 中药戒烟贴与尼古丁贴联合5A方案对烟草依赖人群戒烟效果的对比观察 |
| A Comparative Observation on the Smoking Cessation Efficacy of Chinese Medicine Smoking Cessation Patch Combined with Nicotine Patch and the 5A Program Among Tobacco-dependent Populations |
| 投稿时间：2026-07-15 修订日期：2026-08-10 |
| DOI： |
| 中文关键词: 中药戒烟贴、尼古丁贴、5A方案、烟草依赖、戒烟 |
| 英文关键词: Chinese medicine smoking cessation patch, Nicotine patch, 5A protocol, Tobacco dependence, Smoking cessation |
| 基金项目:江西省中医药管理局厅级一般项目(2022A249) |
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| 中文摘要: |
| 目的：分别观察中药戒烟贴与尼古丁贴联合5A方案对烟草依赖人群的戒烟效果。方法：将就诊于南昌大学第一附属医院的130例患者通过随机数字表法分为2组。由于中药戒烟贴联合5A方案(观察组)中1名患者拒绝参与,最终纳入患者64人。而尼古丁贴联合5A方案(对照组)纳入患者65人。基于5A方案在患者的甜美穴处贴敷中药戒烟贴,在胸部、背部或上臂等部位贴敷尼古丁贴。并在治疗前、治疗后6周、治疗后6个月收集两组患者的每日吸烟量和呼气一氧化碳(CO)浓度。此外,治疗前后6个月同时收集患者的第一秒用力呼气容积占用力肺活量的百分比(FEV1/FVC),治疗结束后调查患者的戒断率、复吸率与满意度。结果：治疗后6个月对照组的吸烟量0支/d占比为89.23%,观察组占比为92.19%,观察组1~20支/d的占比始终低于对照组。另外,患者的FEV1/FVC虽无统计学差异(p>0.05),但是干预后观察组FEV1/FVC≥0.7的占比为78.13%,比对照组高10.44%。同时,两组患者呼气CO浓度的变化趋势与每日吸烟量一致。两组患者的戒断率与复吸率无统计学差异(p>0.05),但是观察组的戒断率高于对照组(82.81%>70.77%),复吸率低于对照组(17.19%<29.23%)。最后,两组患者的满意度差异具有统计学意义(p<0.05),观察组不满意占比3.13%,远低于对照组。结论：中药戒烟贴与尼古丁贴戒烟疗效相当,但中药戒烟贴在患者耐受性和满意度方面更具有优势。 |
| 英文摘要: |
| Objective: To compare the smoking cessation effects of the Chinese medicine smoking cessation patch and the nicotine patch combined with the 5A protocol on tobacco-dependent individuals. Methods: 130 patients visiting the First Affiliated Hospital of Nanchang University were randomly divided into two groups using a random number table. Due to one patient in the observation group (combined with the 5A protocol using the Chinese medicine smoking cessation patch) refusing to participate, a total of 64 patients were included. While 65 patients were included in the control group (combined with the 5A protocol using the nicotine patch). Based on the 5A Program, Chinese medicine smoking cessation patches are applied to the Tianmei acupoint of patients, while nicotine patches are applied to the chest, back, upper arm or other areas. The daily cigarette consumption and exhaled CO concentration of patients were collected before treatment, 6 weeks and 6 months after treatment. In addition, FEV1/FVC was collected before and after treatment for 6 months, and the abstinence rate, relapse rate and satisfaction were investigated after the treatment. Results: At 6 months after treatment, the proportion of patients with 0 cigarettes/day in the control group was 89.23%, and that in the observation group was 92.19%. The proportion of patients with 1~20 cigarettes/day in the observation group was always lower than that in the control group. Moreover, although there was no statistical difference in FEV1/FVC (p>0.05), the proportion of patients with FEV1/FVC ≥0.7 in the observation group after intervention was 78.13%, which was 10.44% higher than that in the control group. At the same time, the trend of exhaled CO concentration change was consistent with the daily smoking quantity. There was no statistical difference in the abstinence rate and relapse rate between the two groups (p>0.05), but the abstinence rate of the observation group was higher than that of the control group (82.81%>70.77%), and the relapse rate was lower than that of the control group (17.19%<29.23%). Finally, the difference in satisfaction between the two groups was statistically significant (p<0.05), with the dissatisfaction rate of the observation group being 3.13%, which was much lower than that of the control group. Conclusion: The smoking cessation efficacy of the Chinese medicine smoking cessation patch and the nicotine patch is comparable, but the Chinese medicine smoking cessation patch has more advantages in terms of patient tolerance and satisfaction. |
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