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| 厄贝沙坦氢氯噻嗪联合美托洛尔治疗高龄患者心功能不全的效果分析 |
| Analysis of the effect of Irbesartan hydrochlorothiazide combined with metoprolol in the treatment of cardiac insufficiency in elderly patients |
| 投稿时间：2025-01-05 修订日期：2025-03-03 |
| DOI： |
| 中文关键词: 心功能不全 厄贝沙坦氢氯噻嗪 美托洛尔 脑钠肽 C反应蛋白 |
| 英文关键词: cardiac insufficiency irbesartan hydrochlorothiazide metoprolol brain natriuretic peptide C-reactive protein |
| 基金项目: |
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| 中文摘要: |
| 目的 探讨厄贝沙坦氢氯噻嗪联合美托洛尔治疗高龄慢性心功能不全的效果。方法 选取2020年1月到2022年12月心内科收治的160例高龄慢性心功能不全患者，信封法随机分为厄贝沙坦组和联合组，每组80例，厄贝沙坦组口服厄贝沙坦氢氯噻嗪片，美托洛尔组在厄贝沙坦组的基础上给予口服琥珀酸美托洛尔缓释片，跟踪随访1年美托洛尔治疗效果。结果 美托洛尔组有效率显著高于厄贝沙坦组，美托洛尔组患者LVESD、LVEDD均较厄贝沙坦组显著下降，LVEF水平较厄贝沙坦组显著升高，美托洛尔组患者血清BNP和CRP水平均显著下降，差异均具有统计学意义（P＜0.05）。不良反应比较差异无统计学意义(P＞0.05)。结论 厄贝沙坦氢氯噻嗪美托洛尔可改善高龄慢性心功能不全患者的心功能指标，降低BNP和CRP水平，促进患者恢复。 |
| 英文摘要: |
| Objective To explore the effect of irbesartan hydrochlorothiazide combined with metoprolol in the treatment of chronic cardiac insufficiency in advanced age. Methods 160 cases of elderly chronic cardiac insufficiency patients admitted to the Department of Cardiology from January 2020 to December 2022 were selected, and were randomly divided into Irbesartan group and combined group by envelope method, with 80 cases in each group. Irbesartan group was given oral irbesartan hydrochlorothiazide tablets, and metoprolol group was given oral metoprolol succinate extended-release tablets based on irbesartan group, and the therapeutic effect of metoprolol was tracked and followed up for 1 year. Results The effective rate of metoprolol group was significantly higher than that of irbesartan group, LVESD and LVEDD of patients and serum BNP and CRP levels of patients in metoprolol group were significantly decreased, and the differences were all statistically significant (P < 0.05). The difference in the comparison of adverse reactions was not statistically significant (P > 0.05). Conclusion Irbesartan hydrochlorothiazide metoprolol can improve the cardiac function indexes of elderly patients with chronic cardiac insufficiency, reduce the levels of BNP and CRP, and promote the recovery of patients. |
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