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| 中药结肠康灌肠治疗溃疡性结肠炎的临床观察 |
| Clinical Evaluation of Jie Chang Kang Enema for the Management of Ulcerative Colitis |
| 投稿时间：2024-12-29 修订日期：2025-01-16 |
| DOI： |
| 中文关键词: 溃疡性结肠炎 结肠康 中药灌肠 肠道菌群 |
| 英文关键词: ulcerative colitis Jie chang kang Chinese medicine enema Gut microbiome |
| 基金项目:湖北省自然科学青年基金(2014AFB522)。 |
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| 中文摘要: |
| 目的 观察中药结肠康灌肠治疗溃疡性结肠炎的临床应用疗效。方法 通过回顾性分析,将符合要求的69例溃疡性结肠炎患者,根据治疗方案分为两组,常规西医治疗的35例患者作为对照组,在常规治疗基础上加用结肠康灌肠的34例患者作为观察组。治疗4周后,比较两组患者治疗前后中医症状积分、大肠镜下粘膜评分(Baron评分)、组织病理学指标(Geboes指数)、四种肠道菌群数量及三项炎症因子(红细胞沉降率、C-反应蛋白、肿瘤坏死因子-α)的变化。结果 治疗后,两组患者中医症状积分、大肠镜下粘膜评分(Baron评分)、组织病理学指标(Geboes指数)、四种肠道菌群数量及三项炎症因子(红细胞沉降率、C-反应蛋白、肿瘤坏死因子-α)比较,观察组均优于对照组(P＜0.05)。结论： 中药结肠康灌肠联合常规治疗能够改善溃疡性结肠炎患者的临床症状,其机制可能与调节肠道菌群紊乱、降低炎症因子水平有关。 |
| 英文摘要: |
| Objective This study aims to assess the clinical effectiveness of Jie chang kang enema in managing ulcerative colitis. Methods A retrospective analysis was performed on 69 patients diagnosed with ulcerative colitis who satisfied the inclusion criteria. Participants were categorized into two groups according to their treatment protocols: a control group (n=35) receiving standard Western medication, and an experimental group (n=34) undergoing additional treatment with Jie chang kang enema alongside conventional therapy. Following a 4-week treatment period, comparisons were made between the two groups regarding changes in Traditional Chinese Medicine (TCM) symptom scores, endoscopic mucosal assessments (using the Baron score), histopathological evaluations (via the Geboes index), counts of four types of gut microbiota, and levels of three inflammatory markers (erythrocyte sedimentation rate, C-reactive protein, and tumor necrosis factor-α).Results Post-treatment comparisons revealed that the observation group showed significant improvements over the control group in TCM symptom scores, endoscopic mucosal scores (Baron score), histopathological indices (Geboes index), counts of four types of intestinal flora, and levels of three inflammatory markers (erythrocyte sedimentation rate, C-reactive protein, tumor necrosis factor-α) (P < 0.05).Conclusion The integration of Jie chang kang enema with standard treatments can effectively mitigate clinical symptoms in ulcerative colitis patients, possibly through the regulation of gut microbiota and reduction of inflammatory factors.Keywords: ulcerative colitis; Jie chang kang; Chinese medicine enema; Gut microbiome |
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