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| 再生障碍性贫血骨髓造血微环境免疫失调的研究进展 |
| Recent Advances in Immunological Dysregulation of the Bone Marrow Hematopoietic Microenvironment in Aplastic Anemia |
| 投稿时间：2024-12-26 修订日期：2025-01-26 |
| DOI： |
| 中文关键词: 再生障碍性贫血 骨髓造血微环境 免疫失调 造血干细胞 |
| 英文关键词: Aplastic anemia Bone marrow hematopoietic microenvironment Immune dysregulation Hematopoietic stem cells |
| 基金项目:CAMS创新工程重点项目(CIFMS, no.2021-I2M-1-028) |
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| 中文摘要: |
| 再生障碍性贫血是一种由免疫系统异常激活介导的获得性骨髓造血功能衰竭性疾病。骨髓造血微环境异常与再生障碍性贫血的发生发展密切相关,异常激活的免疫细胞与造血干细胞之间相互作用,进而导致造血衰竭。本文将重点综述再生障碍性贫血骨髓免疫微环境紊乱的病理特征,以及免疫失调在再生障碍性贫血骨髓造血微环境中的作用。 |
| 英文摘要: |
| Aplastic anemia is an acquired hematopoietic failure disease characterized by the abnormal activation of the immune system. Disruptions in the bone marrow hematopoietic microenvironment are closely linked to the development of AA, where interactions between abnormally activated immune cells and hematopoietic stem cells contribute to hematopoietic failure. This paper will focus on reviewing the pathological features of immune microenvironment dysregulation in the bone marrow of AA and the role of immune dysfunction in the disruption of the hematopoietic microenvironment. |
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