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| 基于动脉粥样硬化血脂指数(AIP)预测慢性阻塞性肺病患者中风风险 |
| Prediction of Stroke Risk in Chronic Obstructive Pulmonary Disease Patients Based on the Atherogenic Index of Plasma (AIP) |
| 投稿时间：2024-11-21 修订日期：2024-12-04 |
| DOI： |
| 中文关键词: 动脉粥样硬化血脂指数（AIP） 慢性阻塞性肺病 中风 NHANES 亚组分析 |
| 英文关键词: Atherogenic Index of Plasma (AIP) Chronic Obstructive Pulmonary Disease (COPD) Stroke NHANES Subgroup Analysis |
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| 中文摘要: |
| 摘要
目的
本研究旨在评估动脉硬化脂蛋白指数（AIP）与慢性阻塞性肺病（COPD）患者中风风险之间的关系，以探讨AIP作为中风风险预测指标的潜在价值。
方法
基于美国国家健康与营养调查（NHANES）数据，分析了3083名COPD患者的中风风险，其中633人有中风史。通过多因素Logistic回归、亚组分析和限制性立方样条（RCS）分析，系统评估AIP与中风风险的关系及其在不同亚组中的表现。
结果
基线描述显示，AIP在中风组患者中显著高于无中风组。在多因素Logistic回归中，AIP每增加1单位，中风风险增加2.28倍（95%CI: 1.723.03）；在四分位数分析中，最高四分位组中风风险为最低组的2.22倍（95%CI: 1.593.11）。亚组分析揭示了AIP对特定人群中风险的显著影响，尤其是年龄≥50岁（OR=5.33）、超重（OR=7.04）和当前吸烟者（OR=4.02）。RCS分析未显示显著非线性关系（P=0.168），但在AIP超过0.0672时，中风风险明显上升。
结论
AIP升高与COPD患者中风风险显著相关，且在特定亚组中效果尤为显著。AIP在COPD患者中可能作为中风风险预测指标，具有潜在临床应用价值。 |
| 英文摘要: |
| Abstract
Objective
This study aimed to evaluate the relationship between the Atherogenic Index of Plasma (AIP) and stroke risk in patients with Chronic Obstructive Pulmonary Disease (COPD) to explore AIP’s potential as a predictive indicator for stroke risk.
Methods
Data were derived from the National Health and Nutrition Examination Survey (NHANES), including 3,083 COPD patients, of whom 633 had a history of stroke. Multivariable logistic regression, subgroup analysis, and Restricted Cubic Spline (RCS) analysis were employed to assess the association between AIP and stroke risk and its variation across subgroups.
Results
Baseline characteristics showed significantly higher AIP levels in the stroke group compared to the non-stroke group. Multivariable logistic regression indicated that each 1-unit increase in AIP was associated with a 2.28-fold increase in stroke risk (95% CI: 1.72–3.03). Quartile analysis revealed that those in the highest quartile had 2.22 times the stroke risk of those in the lowest quartile (95% CI: 1.59–3.11). Subgroup analysis demonstrated a stronger association in specific populations, particularly in those aged ≥50 years (OR=5.33), those overweight (OR=7.04), and current smokers (OR=4.02). Although RCS analysis did not indicate a significant non-linear relationship (P=0.168), an upward trend in stroke risk was evident when AIP exceeded 0.0672.
Conclusion
Elevated AIP was significantly associated with increased stroke risk in COPD patients, with particularly pronounced effects in certain subgroups. AIP may have clinical utility as a predictive indicator of stroke risk in COPD patients. |
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