| Objective: To analyze the research status of Hedyotis diffusa and Scutellaria lobata in anti-cervical cancer, in order to provide some reference for the research of Hedyotis diffusa and Scutellaria lobata in anti-cervical cancer in our country. Methods: The studies on the anti-cervical cancer effects of Hedtis alba and Lobata alba were searched in China National Knowledge Infrastructure (CNKI), VIP, Wanfang Database, PubMed and SinoMed database from the establishment of the database to October 11, 2024. The included literature information included author, publication time, journal, research institution, etc. The experimental models, pathway targets, experimental effects/mechanisms of Hedyotis diffusa and Scutellaria bungebra were retrospectively analyzed. Results: A total of 27 experimental articles that met the requirements were collected, of which 16 were related to Hedyotis diffusa, involving 11 authors. There were 11 articles related to Scutellaria hirsutum, involving 10 authors. The aided publication rates were 50% and 81.8%, respectively. More than half of the studies used cell models. 37.5% of the studies suggested that the anti-cervical cancer mechanism of Hedyotis diffusa was related to Ki-67 gene, and 27.2% of the studies suggested that the anti-cervical cancer mechanism of Scutellaria hirsutum was related to VEGF targets. Conclusions: The results show that there are few articles on the experimental research of Hedtis diffusa and Scuteletes herba against cervical cancer in the past 20 years, the proportion and level of fund funding are relatively high, and the depth of research on their mechanism is not enough. However, the research enthusiasm and innovation in this field need to be improved. |
