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| 定坤丹联合重组人生长激素对卵巢低反应患者体外受精-胚胎移植结局的影响 |
| The Effect of Dingkun pill combined with recombinant human growth hormone on the outcomes of in vitro fertilization-embryo transfer in women with poor ovarian response |
| 投稿时间：2024-10-10 修订日期：2024-10-25 |
| DOI： |
| 中文关键词: 定坤丹 生长激素 卵巢低反应 |
| 英文关键词: Dingkun pill Growth hormone Poor ovarian response |
| 基金项目:江西省中医药管理局科技计划项目（2022B163）；江西省自然科学基金（20224BAB216026）；江西省省级临床重点专科建设项目； |
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| 中文摘要: |
| 目的： 探讨促排卵过程中联合使用定坤丹及重组人生长激素对卵巢低反应患者体外受精-胚胎移植结局的影响
方法： 采用回顾性研究，分析2020年7月至2023年7月就诊于江西省妇幼保健院辅助生殖中心，行高孕激素状态下促排卵方案（progestin-primed ovarian stimulation ，PPOS）的卵巢低反应患者临床资料，按照是否联用定坤丹及重组人生长激素注射液，分为治疗组 (n = 235)，对照组 (n = 509)，分析比较两组患者基本情况、治疗情况及临床结局
结果： 本研究共纳入744个周期，两组患者年龄、身体质量指数（body mass index，BMI）无显著性差异（P＞0.05），ICSI卵子成熟率（79.82％ vs 70.92％）、优质胚胎率（40.12％ vs 32.33％），多胎率（9.3％ vs 28 ％）具有统计学意义（P＜0.05）
结论： PPOS方案促排卵期间联用定坤丹及生长激素可提高ICSI卵子成熟率、优质胚胎率，提示定坤丹联用生长激素对卵子质量、胚胎质量有一定改善作用 |
| 英文摘要: |
| Objective: To investigate the effect of combination of Dingkun pill and recombinant human growth hormone on the outcome of IVF and embryo transfer in patients with poor ovarian response during ovulation induction Methods：A retrospective study was conducted to analyze the clinical data of patients with poor ovarian response who were admitted to the Assisted Reproduction Center of Jiangxi Maternal and Child Health Hospital from July 2020 to July 2023 and received ovulation induction regimen with high progesterone. The patients were divided into treatment group (n = 235) according to whether they were combined with Dingkun pill and recombinant human growth hormone injection. Control group (n = 509), the basic situation, treatment and clinical outcome of the two groups were analyzed and compared Results: A total of 744 cycles were included in this study, and there was no significant difference in age, body mass index (BMI), ICSI egg maturity rate (79.82% vs 70.92%), and high-quality embryo rate (40.12% vs 32.33%) between the two groups. The multiple birth rate (9.3% vs 28%) was statistically significant (P < 0.05).Conclusion: The combination of Dingkun pill and growth hormone during ovulation induction of PPOS can improve the egg maturity rate and high-quality embryo rate of ICSI, suggesting that Dingkun pill combined with growth hormone can improve egg quality and embryo quality to some extent |
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