| 徐灿灿,李君,张鹏举.小儿肺热咳喘颗粒联合头孢唑肟钠注射液治疗痰热闭肺型小儿肺炎喘嗽的应用价值[J].实用中西医结合临床,2025,25(2): |
| 小儿肺热咳喘颗粒联合头孢唑肟钠注射液治疗痰热闭肺型小儿肺炎喘嗽的应用价值 |
| The application value of paediatric lung-heat cough granules combined with cefozoxime injection in the treatment of phlegm-heat-shut lung type paediatric pneumonia and wheezing |
| 投稿时间：2024-06-12 修订日期：2024-08-01 |
| DOI： |
| 中文关键词: 小儿肺炎 痰热闭肺型 喘嗽 肺热咳喘颗粒 头孢唑肟注射液 |
| 英文关键词: pneumonia asthma phlegm-heat closed lung type lung-heat cough and asthma granules cefozoxime injection |
| 基金项目:河南省医学科技攻关计划联合共建项目（LHGJ20230849） |
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| 中文摘要: |
| 目的 探讨痰热闭肺型小儿肺炎喘嗽应用肺热咳喘颗粒与头孢唑肟注射液协同治疗的价值。方法 选择2022年3月~2024年4月医院接诊的肺炎喘嗽患儿100例，按照简单随机盲选法分为实验组与对照组，各50例。对照组在常规对症治疗基础上，予以头孢唑肟注射液治疗，实验组在对照组用药基础上，加用肺热咳喘颗粒治疗。对比两组治疗前、治疗7 d、治疗14 d后中医证候积分、血清炎症因子[白细胞介素-1β（IL-1β）、降钙素原（PCT）、C反应蛋白（CRP）]、肺部功能[潮气量（TV）、每分钟通气量（VE）、用力肺活量（FVC）、第1秒用力呼气容积（FEV1）]以及不良反应发生情况。结果 治疗7 d、治疗14 d，两组中医证候积分主症、次症与总分、IL-1β、PCT、CRP均比治疗前降低，且实验组更低（P＜0.05）；两组TV、VE、FVC、FEV1均比治疗前升高，且实验组更高（P＜0.05）；实验组不良反应发生率为4.00%，比对照组的16.00%低（P＜0.05）。结论 痰热闭肺型小儿肺炎喘嗽应用肺热咳喘颗粒与头孢唑肟注射液协同治疗，可降低患儿血清炎症因子水平，改善患儿肺部功能，减轻患儿临床体征，安全性较高。 |
| 英文摘要: |
| Objective To explore the value of applying the synergistic treatment of paediatric lung-heat cough and asthma granules with cefozoxime injection in phlegm-heat-shut lung type of paediatric pneumonia and wheezing. Methods From March 2022 to April 2024, 100 children with pneumonia and cough received by the Department of Integrative Chinese and Western Medicine of the hospital were selected and divided into the experimental group and the control group according to the simple random blind selection method, with 50 cases each. The control group was treated with cefazoxime injection on the basis of conventional symptomatic treatment, and the experimental group was treated with Ferekechuan granules on the basis of the control group. Before treatment, 7 days after treatment, 14 days after treatment, TCM symptom scores, serum inflammatory factors [interleukin-1β (IL-1β), procalcitonin (PCT), C-reactive protein (CRP)], lung function [tidal volume (TV), minute ventilation volume (VE), forced vital capacity (FVC), first second forced vital capacity (FEV1)] of the two groups were compared. Compare adverse reactions. Results After 7 days of treatment and 14 days of treatment, the main symptom score, secondary symptom score and total score, IL-1β, PCT and CRP in two groups were lower than before treatment, and the experimental group was lower (P < 0.05). The levels of TV, VE, FVC and FEV1 in 2 groups were higher than before treatment, and those in experimental group were higher (P < 0.05). The incidence of adverse reactions in experimental group was 4.00%, which was lower than that in control group (16.00%) (P < 0.05). Conclusion The application of lung-heat cough and asthma granules and cefozoxime injection in synergistic treatment of paediatric pneumonia with phlegm-heat closed lung type can reduce the level of serum inflammatory factors, improve the function of lungs and reduce the clinical signs of the children with a high degree of safety. |
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