|
| 车前子联合头孢曲松对产β-内酰胺酶淋病奈瑟菌的体外抑菌效果研究 |
| The Inhibitory EffectS of Plantago Seed Combined with Ceftriaxone against β-lactamase Neisseria gonorrhoeae in Vitro |
| 投稿时间：2024-06-11 修订日期：2024-06-26 |
| DOI： |
| 中文关键词: 车前子乙醇提取物 头孢曲松 β-内酰胺酶 淋病奈瑟菌 体外抑菌 |
| 英文关键词: Ethanol Extract of Plantago Seed Ceftriaxone β- Lactamase Neisseria gonorrhoeae In Vitro Bacteriostasis |
| 基金项目:江西省中医药管理局科技计划 |
|
| 摘要点击次数: 6 |
| 全文下载次数: 0 |
| 中文摘要: |
| 摘要：目的 探讨车前子乙醇提取物联合头孢曲松对产β-内酰胺酶淋病奈瑟菌的体外抑菌效果。方法 采用微量肉汤稀释法分别测试车前子乙醇提取物和头孢曲松的单药最低抑菌浓度及两药联合时的部分抑菌浓度指数。结果 头孢曲松对产β-内酰胺酶淋病奈瑟菌的最低抑菌浓度为0.06μg/mL；车前子乙醇提取物对产β-内酰胺酶淋病奈瑟菌的最低抑菌浓度为128μg/mL；两药联合时的部分抑菌浓度指数（FIC）为1，提示两药联合用药时为相加作用，抗菌活性稍有增加。结论 车前子乙醇提取物对产β-内酰胺酶淋病奈瑟菌具有良好的抑菌活性；头孢曲松对产β-内酰胺酶淋病奈瑟菌的体外抑菌活性较高；头孢曲松可以联合车前子乙醇提取对产β-内酰胺酶淋病奈瑟菌进行抑菌作用，但效果不显著。 |
| 英文摘要: |
| Abstract: Objective To explore the inhibitory effects of ethanol extract of Plantago seed combined with ceftriaxone against productionβ-lactamase Neisseria gonorrhoeae in vitro. Methods The minimum inhibitory concentration of single drug and the partial inhibitory concentration index of the combination of ethanol extract of Plantago seed and ceftriaxone were tested by microbroth dilution method. Test the fractional inhibitory concentration index of the dual drug combination using the micro broth chessboard dilution method. Results The minimum inhibitory concentration of ceftriaxone against Neisseria gonorrhoeae with lactamase is 0.06μg/mL. The minimum inhibitory concentration of ethanol extract of Plantago seed on production β-lactamase Neisseria gonorrhoeae is 128μg/mL. The fractional inhibitory concentration index （FIC）of the combination of the two drugs is 1, indicating that the antibacterial activity was slightly increased when the two drugs were combined. Conclusions The ethanol extract of Plantago seed has good antibacterial activity against producing β- Lactamase Neisseria gonorrhoeae. The antibacterial activity of ceftriaxone for producing β- Lactamase Neisseria gonorrhoeae is relatively high in vitro .Ceftriaxone can be combined with the ethanol extract of Plantago seed to inhibit β-lactamase-producing Neisseria gonorrhoeae, but the effect is not significant. |
|
View Fulltext
查看/发表评论 下载PDF阅读器 |
| 关闭 |
