| 罗钊琰，唐征宇.杞菊地黄汤加减联合西药对妊娠期糖尿病患者糖脂代谢、妊娠结局的影响[J].实用中西医结合临床,2023,23(19):6-9,17 |
| 杞菊地黄汤加减联合西药对妊娠期糖尿病患者糖脂代谢、妊娠结局的影响 |
| Effects of Qijudihuang Decoction Plus or Minus Combined with Western Medicine on Glycolipid Metabolism and Pregnancy Outcome in Patients with Gestational Diabetes Mellitus |
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| DOI： |
| 中文关键词: 妊娠期糖尿病 杞菊地黄汤 胰岛素 糖脂代谢 妊娠结局 |
| 英文关键词: Gestational diabetes mellitus Qijudihuang decoction Insulin Glycolipid metabolism Pregnancy outcome |
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| 中文摘要: |
| 目的：评价妊娠期糖尿病（GDM）患者接受杞菊地黄汤加减联合西药治疗的疗效，并分析该联合方案对患者糖脂代谢、妊娠结局的影响。方法：选择2021年1月至2022年6月就诊于湖南省直中医医院的90例GDM患者，按随机对照原则分组。对照组（45例）接受胰岛素治疗，研究组（45例）接受杞菊地黄汤加减联合胰岛素治疗，共治疗4周，并随访至分娩后。对比两组临床疗效、血糖水平、血脂水平、不良妊娠结局以及不良反应发生率。结果：治疗4周后临床总有效率比较，研究组高于对照组（P＜0.05）；研究组治疗4周后糖化血红蛋白（HbA1c）、空腹血糖（FPG）以及餐后2 h血糖（2 h PG）水平比对照组低（P＜0.05）；研究组治疗4周后低密度脂蛋白胆固醇（LDL-C）、甘油三酯（TG）、总胆固醇（TC）水平比对照组低（P＜0.05）；两组不良反应发生率、不良妊娠结局发生率比较相当，差异无统计学意义（P＞0.05）。结论：杞菊地黄汤加减联合胰岛素治疗GDM，能有效改善患者的糖脂代谢水平，临床疗效好，用药安全性高。 |
| 英文摘要: |
| Objective: To evaluate the therapeutic effect of Qijudihuang decoction plus or minus combined with western medicine on patients with gestational diabetes mellitus (GDM), and to analyze the effects of the combined regimen on glycolipid metabolism and pregnancy outcome. Methods: A total of 90 GDM patients admitted to Hunan provincial direct hospital of traditional chinese medicine from January 2021 to June 2022 were selected and grouped into randomized control groups. The control group (45 cases) receiving insulin therapy and the study group (45 cases) receiving Qijudihuang decoction plus or minus insulin therapy were treated for a total of 4 weeks, and followed up until delivery. The clinical efficacy, blood glucose level, blood lipid level, adverse pregnancy outcome and incidence of adverse reactions were compared between the two groups. Results: After 4 weeks of treatment, the total effective rate of the study group was better than that of the control group (P＜0.05). The levels of glycosylated hemoglobin (HbA1c), fasting blood glucose (FPG) and 2 h postprandial blood glucose (2 h PG) in the study group after 4 weeks of treatment were lower than those of the control group (P＜0.05). After 4 weeks of treatment, the levels of low-density lipoprotein cholesterol (LDL-C), triglyceride (TG) and total cholesterol (TC) in the study group were lower than those of the control group (P＜0.05). The incidence of adverse reactions and adverse pregnancy outcomes were similar between the two groups, but the difference was not significant (P＞0.05). Conclusion: Qijudihuang decoction plus or minus combined with western medicine can effectively improve the level of glycolipid metabolism of patients with GDM, with good clinical efficacy and high drug safety. |
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