文章摘要
陈魁.2020-2022年樟树市儿童接种麻腮风疫苗后出现异常反应的相关因素分析及对策研究[J].实用中西医结合临床,2023,23(22):
2020-2022年樟树市儿童接种麻腮风疫苗后出现异常反应的相关因素分析及对策研究
Analysis of related factors and countermeasures of abnormal reactions of children receiving MMR vaccine in Zhangshu City from 2020 to 2022
投稿时间:2023-08-11  修订日期:2023-10-10
DOI:
中文关键词: 麻腮风疫苗接种  异常反应  相关因素分析  儿童  麻腮风联合减毒活疫苗
英文关键词: MMR vaccination  Abnormal reaction  Analysis of related factors  Children  MMR combined live attenuated vaccine
基金项目:
作者单位E-mail
陈魁* 江西省樟树市疾病预防控制中心 zhaona079211@163.com 
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中文摘要:
      [摘要]目的 探讨2020-2022年樟树市儿童接种麻腮风疫苗后出现异常反应的相关因素分析及对策研究。方法 选择2020-2022年樟树市接种麻腮风疫苗的8-24个月龄儿童,共接种麻腮风疫苗24321剂次,并记录麻腮风疫苗接种后出现异常反应的情况,分析麻腮风疫苗接种后出现异常反应的相关影响因素。结果 2020-2022年樟树市接种麻腮风疫苗后出现异常反应的儿童共20例(8.22? ),其中局部硬结发生率最高,其次是局部疼痛、过敏性皮疹、发热、呕吐、淋巴结肿大、阵发性抽搐、腹泻。单因素分析显示,年龄8-12个月、第1次接种麻腮风疫苗、曾经接种疫苗后出现过异常反应、居住地农村与麻腮风疫苗接种后出现异常反应有关,差异有统计学意义(P<0.05);性别、疫苗接种月份与麻腮风疫苗接种后出现异常反应无关,差异无统计学意义(P>0.05)。经Logistic回归分析显示,年龄8-12个月(β=1.582,OR=4.865,95%CI=1.768-13.391)、第1次接种麻腮风疫苗(β=1.621,OR=5.057,95%CI=1.690-15.132)、曾经接种疫苗后出现过异常反应(β=8.968,OR=7851.148,95%CI=4001.103-15405.883)、居住地农村(β=1.082,OR=2.949,95%CI=1.205-7.217)是麻腮风疫苗接种后出现异常反应的高危因素(P<0.05)。结论 儿童接种麻腮风疫苗后出现异常反应受年龄、第几次接种麻腮风疫苗、曾经接种疫苗后是否出现过异常反应、居住地多种因素影响。
英文摘要:
      [Abstract] Objective To investigate the related factors and countermeasures of abnormal reaction of children receiving MMR vaccine in Zhangshu City from 2020 to 2022. Methods Children aged 8-24 months who received MMR vaccine in Zhangshu City from 2020 to 2022 were selected to collect data and record the abnormal reactions after MMR vaccine. The related influencing factors of the abnormal reactions after MMR vaccine were analyzed. Results There were 20 cases (8.22? ) of children with abnormal reaction after receiving MMR vaccine in Zhangshu City from 2020 to 2022. The incidence of local induration was the highest, followed by local pain, allergic rash, fever, vomiting, lymph node enlargement, paroxysm, diarrhea. Univariate analysis showed that the age of 8-12 months, the first time receiving MMR vaccine, the abnormal reaction after vaccination, and the rural area of residence were associated with the abnormal reaction after MMR vaccine, and the difference was statistically significant (P < 0.05). Gender and vaccination month were not associated with abnormal reactions after MMR vaccination, and there was no statistical significance (P > 0.05). Logistic regression analysis showed that the age of 8-12 months (β=1.582, OR=4.865, 95%CI=1.768-13.391), the first vaccination with MMR vaccine (β=1.621, OR=5.057, 95%CI=1.690-15.132), had an abnormal reaction after vaccination (β=8.968, OR=7851.148, 95%CI=4001.103-15405.883), lived in rural areas (β=1.082, OR=2.949, 95%CI=1.205-7.217) was the risk factor for abnormal reaction after MMR vaccination (P < 0.05). Conclusion The age, the number of MMR vaccination, the occurrence of abnormal reaction after vaccination and the place of residence of children affected the abnormal reaction after vaccination.
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