| 罗琪明，刘宁，何炜，李欣，郑碧武，何娜.硝石化生汤熏洗对复杂性肛瘘术后创面愈合、疼痛程度、血清炎症因子影响研究[J].实用中西医结合临床,2023,23(5):5-8 |
| 硝石化生汤熏洗对复杂性肛瘘术后创面愈合、疼痛程度、血清炎症因子影响研究 |
| Study on the Effects of Saltpeter Huasheng Decoction Fumigation and Washing on Wound Healing, Pain Degree and Serum Inflammatory Factors after Complex Anal Fistula |
| |
| DOI： |
| 中文关键词: 复杂性肛瘘 手术 硝石化生汤 熏洗 疗效 创面愈合 肛门功能 |
| 英文关键词: Complex anal fistula Surgery Saltpeter huasheng soup Fumigation Curative effect Wound healing Anus function |
| 基金项目:四川省中医药管理局科学技术研究专项（编号：2020LC0167） |
|
| 摘要点击次数: 105 |
| 全文下载次数: 67 |
| 中文摘要: |
| 目的：观察硝石化生汤熏洗对复杂性肛瘘术后创面愈合、疼痛程度、血清炎症因子影响。方法：将射洪市中医院及遂宁市中心医院、遂宁市中医院收治的270例复杂性肛瘘手术患者（2021年1~11月）纳入研究，将患者以随机数字表法分为两组，各135例。对照组术后常规应用抗生素及止血手段等治疗，观察组则另外加用硝石化生汤实施熏洗方式治疗，比较两组临床疗效、中医证候总积分、创面愈合时间、肛门失禁wexner评分及术后3 d、7 d、10 d疼痛评分[视觉模拟评分法（VAS）]、术后并发症、治疗前后血清白细胞介素-6（IL-6）、白细胞介素-2（IL-2）及肿瘤坏死因子-α（TNF-α）炎症因子水平。结果：观察组治疗总有效率（98.52%）比对照组（92.59%）更高（P＜0.05）；观察组治疗后创面愈合时间短于对照组，肛门失禁wexner评分低于对照组（P＜0.05）；观察组术后并发症率（1.48%）低于对照组（6.67%）（P＜0.05）；术后3 d、7 d、10 d观察组VAS评分均低于对照组（P＜0.05）；治疗前，两组中医证候总积分、IL-6、IL-2、TNF-α水平比较无明显差异（P＜0.05），两组治疗后中医证候总积分、IL-6、IL-2、TNF-α水平均改善，观察组治疗后中医证候总积分、IL-6、IL-2、TNF-α水平均优于对照组（P＜0.05）。结论：硝石化生汤熏洗可提升复杂性肛瘘手术患者临床疗效，缓解手术结束后的疼痛，降低血清炎症因子水平及并发症，术后创面愈合快。 |
| 英文摘要: |
| Objective: To observe the effects of Saltpeter Huasheng decoction fumigation and washing on wound healing, pain degree and serum inflammatory factors after complex anal fistula. Methods: 270 cases of complicated anal fistula patients admitted to Shehong Hospital of Traditional Chinese Medicine, Suining Central Hospital and Suining Hospital of Traditional Chinese Medicine from January 2021 to November 2021 were included in this study. The invalids were divided into 2 groups by random number table method, each group included 135 cases. The control group was routinely treated with antibiotics and hemostatic therapy after surgery. On the basis of treatment in the control group, patients in the observation group were treated by fumigation and washing with Saltpeter Huasheng decoction. Data observation: Clinical efficacy, changes of total scores of TCM syndromes before and after treatment, wound healing time after treatment and wexner scores of anal incontinence, pain scores of patients at 3 d, 7 d and 10 d after surgery (visual analogue pain score, VAS), postoperative complications, serum interleukin-2 (IL-2), interleukin6 (IL-6), tumor necrosis factor α (TNF-α ) levels before and after treatment. Results: The total effective rate of the observation group (98.52%) was higher than that of the control group(92.59%) (P＜0.05). The wound healing time in the observation group was shorter than that in the control group, and the wexner score of anal incontinence in the observation group were lower than those in the control group (P＜0.05). The rate of postoperative complications in the observation group (1.48%) was lower than that in the control group (6.67%) (P＜0.05); VAS scores of observation group was lower than that in the control group at 3 d, 7 d and 10 d after surgery (P＜0.05). Before treatment, the total TCM syndrome score, IL-2, IL-6 and TNF-α levels in 2 groups were compared (P＜0.05); after treatment, the total TCM syndrome score, IL-2, IL-6 and TNF-α levels in 2 groups were improved; the total TCM syndrome score, IL-2, IL-6 and TNF-α levels in observation group were better than those in the control group (P＜0.05). Conclusion: The fumigation and washing of Saltpeter Huasheng decoction can improve the clinical efficacy of invalids undergoing complicated anal fistula surgery, relieve postoperative pain, reduce serum inflammatory factors and complications, and the anal function of patients recovered well after surgery, and the wound healed quickly, which is worthy of application. |
|
查看全文
查看/发表评论 下载PDF阅读器 |
| 关闭 |
|
|
|
