| 李朝清.银杏叶制剂联合地塞米松在老年突聋治疗中对血清炎症指标的影响[J].实用中西医结合临床,2022,22(18): |
| 银杏叶制剂联合地塞米松在老年突聋治疗中对血清炎症指标的影响 |
| Effects of Ginkgo biloba preparation combined with dexamethasone on serum inflammatory indexes in the treatment of senile deafness |
| 投稿时间：2022-09-22 修订日期：2022-10-26 |
| DOI： |
| 中文关键词: 银杏叶制剂 地塞米松 老年人 突发性耳聋 炎症因子 |
| 英文关键词: Ginkgo biloba preparation dexamethasone elderly sudden deafness inflammatory factors. |
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| 中文摘要: |
| 目的: 探讨银杏叶制剂联合地塞米松在老年突聋治疗中对血清炎症指标的影响。方法: 按随机数字表法将我院2016年7月-2021年7月收治的102例老年突聋患者分入两组（各51例）。对照组用地塞米松治疗，治疗组加用银杏叶制剂治疗。观察两组治疗前后纯音听阈和血管内皮功能指标[超氧化物歧化酶（SOD）、脂质过氧化物（LPO）、一氧化氮（NO）]、血清炎症指标[肿瘤坏死因子-α（TNF-α）、C反应蛋白（CRP）、白细胞介素-6（IL-6）]，分析其疗效与不良反应。结果: 与对照组比较，治疗组总有效率更高（96.08％vs 82.35％）（χ2=4.993，P=0.025）；两组治疗后各频率点阈值均下降，且相比对照组，治疗组治疗后各频率点阈值更低（P<0.05）；治疗后两组SOD、NO水平均升高，LPO水平降低（P<0.05），且相比对照组，治疗组治疗后SOD、NO水平更高，LPO水平更低（P<0.05）；治疗后两组血清TNF-α、CRP、IL-6水平降低，且相比对照组，治疗组TNF-α、CRP、IL-6水平更低（P<0.05）；治疗组不良反应发生率5.88％，对照组为9.80％，两组比较差异无统计学意义（P=0.543，χ2=0.461）。结论: 银杏叶制剂联合地塞米松治疗老年突聋患者疗效理想，能恢复各频率点听力，安全可靠，推测改善患者血管内皮功能和炎症因子水平是其重要作用机制。 |
| 英文摘要: |
| Objective: To explore the effect of Ginkgo biloba preparation combined with dexamethasone on serum inflammatory indexes in the treatment of senile deafness. Methods: By the random number table, 102 cases with sudden senile deafness admitted to our hospital from July 2016 to July 2021 were divided into two groups (51 cases in each group). The control group was treated with dexamethasone, and the treatment group was additionally treated with ginkgo biloba preparation. The pure tone hearing threshold and vascular endothelial function indexes [superoxide dismutase (SOD), lipid peroxide (LPO), nitric oxide (NO)], serum inflammatory indexes [tumor necrosis factor-α (TNF-α), C-reactive protein (CRP), and interleukin-6 (IL-6)] before and after treatment in the two groups were observed, and efficacy and side reactions were analyzed. Results: The effective rate in treatment group was higher than that in the control group (96.08% vs 82.35%)(χ2=4.993, P=0.025). The thresholds of each frequency point in the two groups decreased after treatment, and the threshold of each frequency point in the treatment group after treatment was lower compared with control group(P<0.05). , The levels of SOD and NO in the two groups were increased after treatment, and the level of LPO was decreased(P<0.05). , The levels of SOD and NO in the treatment group were higher after treatment compared with the control group, and the level of LPO was lower(P<0.05). The serum levels of TNF-α, CRP, and IL-6 in the two groups decreased after treatment, and the levels of TNF-α, CRP, and IL-6 in the treatment group were lower compared with the control group(P<0.05). The rate of side reactions was 5.88% in the treatment group and 9.80% in the control group without significant difference (P=0.543, χ2=0.461). Conclusion: Ginkgo biloba preparation combined with dexamethasone has an ideal curative effect in the treatment of senile sudden deafness, and can restore hearing at various frequency points, which is safe and reliable. It is speculated that improving the vascular endothelial function and the level of inflammatory factors is an important mechanism of action. |
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