| 王利勤，熊鸣峰，王腾宇，万海同，熊墨年，吴春红.基于网络药理学探讨附子甘草配伍治疗慢性心力衰竭的作用机制[J].实用中西医结合临床,2022,22(7):1-6,20 |
| 基于网络药理学探讨附子甘草配伍治疗慢性心力衰竭的作用机制 |
| Study on the Mechanism of Radix Aconiti Laterlis Combined with Radix Glycyrrhizae in the Treatment of Chronic Heart Failure Based on Network Pharmacology |
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| DOI： |
| 中文关键词: 慢性心力衰竭 附子 甘草 配伍 网络药理学 |
| 英文关键词: Chronic heart failure Radix aconiti laterlis Radix glycyrrhizae Compatibility Network pharmacology |
| 基金项目:国家自然科学基金项目（编号：No.81904087）；2019年全国中医药创新骨干人才培训项目[编号：国中医药办人教函（2019）128号]；2020年江西省中医药中青年骨干人才培养项目（第一批）[编号：赣中医科教字（2020）2号]；江西省科技厅重点研发项目（编号：No.20203BBE52W010）； 熊墨年国医名师传承工作室[编号：赣中医药综合字（2021）12号] |
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| 中文摘要: |
| 目的：基于网络药理学阐明附子甘草配伍对慢性心力衰竭的作用机制。方法：通过数据库TCMSP、TCM、STITCH以及OMIM、Gene Card对附子甘草配伍的化学成分、成分靶点以及疾病靶点分别进行检索。再对相关疾病靶点和药物潜在靶点进行分析，制作韦恩图，筛选出共同交集。分别在David数据库和Bioconductor数据库中对合并所得的候选靶点进行GO富集分析和KEGG通路注释分析。结果：本研究共筛选出附子甘草配伍中的81个化合物，对应的成分靶点169个。同时通过对慢性心力衰竭的检索得到8 668个对应靶点，通过制作韦恩图了解到附子甘草配伍药对的潜在靶点与慢性心力衰竭的潜在靶点共有154个交集，5条相关的信号通路。结论：附子甘草配伍治疗慢性心力衰竭的作用机制可能与调节AKT、MAPK等相关信号通路有关，其中AKT是其主要信号通路。且附子甘草配伍治疗慢性心力衰竭作用与细胞凋亡及白介素-6、肿瘤坏死因子等细胞因子的表达密切相关，表示细胞凋亡、白介素-6、肿瘤坏死因子可能是附子甘草配伍治疗慢性心力衰竭的重要作用靶点。 |
| 英文摘要: |
| Objective:To clarify the mechanism of compatibility of Radix aconiti laterlis and Radix glycyrrhizae on chronic heart failure based on network pharmacology. Methods:The chemical components, component targets and disease targets of compatibility of Radix aconiti laterlis and Radix glycyrrhizae were searched through the databases TCMSP, TCM, STITCH, OMIM and Gene Card. Then analyzed the related disease targets and potential drug targets, made Venn diagram, and screened out the common intersections. Go enrichment analysis and KEGG pathway annotation analysis were performed on the merged candidate targets in David database and Bioconductor database respectively. Results: In this study, 81 compounds in the compatibility of Radix aconiti laterlis and Radix glycyrrhizae were screenedout, and 169 corresponding component targets were selected. At the same time, 8 668 corresponding targets were obtained through the retrieval of chronic heart failure. By making Venn diagram, it was found that there were 154 intersections and 5 related signal pathways between the potential targets of compatibility of Radix aconiti laterlis and Radix glycyrrhizae and the potential targets of chronic heart failure. Conclusion: The mechanism of compatibility of Radix aconiti laterlis and Radix glycyrrhizae in the treatment of chronic heart failure may be related to the regulation of AKT, MAPK and other related signaling pathways, of which AKT is the main signaling pathway. Moreover, the effect of compatibility of Radix aconiti laterlis and Radix glycyrrhizae in the treatment of chronic heart failure is closely related to apoptosis, the expression of cytokines such as interleukin-6 and tumor necrosis factors. It indicates that apoptosis, interleukin-6 and tumor necrosis factor may be important targets for the compatibility of Radix aconiti laterlis and Radix glycyrrhizae in the treatment of chronic heart failure. |
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