| 张鸿雁，秦鸿.十味龙胆花胶囊联合乙酰半胱氨酸胶囊治疗痰热壅肺型老年肺炎疗效观察[J].实用中西医结合临床,2022,22(6):11-14 |
| 十味龙胆花胶囊联合乙酰半胱氨酸胶囊治疗痰热壅肺型老年肺炎疗效观察 |
| Efficacy of Shiweilongdanhua Capsule Combined with Acetylcysteine Capsule in the Treatment of Senile Pneumonia of Phlegm-Heat Obstructing Lung Syndrome |
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| DOI： |
| 中文关键词: 老年肺炎 痰热壅肺型 十味龙胆花胶囊 乙酰半胱氨酸胶囊 |
| 英文关键词: Senile pneumonia Phlegm-heat obstructing lung syndrome Shiweilongdanhua Capsule Acetylcysteine capsule |
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| 中文摘要: |
| 目的：探讨十味龙胆花胶囊联合乙酰半胱氨酸治疗痰热壅肺型老年肺炎的疗效，及对患者外周血中性粒细胞/淋巴细胞比值（NLR）与血小板/淋巴细胞比值（PLR）的影响。方法：采用随机数字表法将2019年1月至2021年10月收治的107例痰热壅肺型老年肺炎患者分为观察组54例和对照组53例。对照组采用乙酰半胱氨酸胶囊治疗，观察组在此基础上联合十味龙胆花胶囊治疗。观察两组治疗前后血清相关指标[白介素-8（IL-8）、C反应蛋白（CRP）、白介素-6（IL-6）]水平和外周血PLR、NLR水平。观察两组临床疗效、不良反应发生情况、血氧饱和度恢复时间以及症状消退和住院时间。结果：治疗前两组IL-8、IL-6、CRP、PLR、NLR水平比较，差异无统计学意义（P＞0.05）；治疗5 d、10 d后，观察组IL-8、IL-6、CRP、PLR、NLR水平均显著低于对照组（P＜0.05）。观察组治疗总有效率为96.30%，显著高于对照组的84.91%（?字2=4.096，P=0.043）。观察组血氧饱和度恢复、症状消退、住院时间均显著短于对照组（P＜0.05）。观察组不良反应发生率为7.41%，略低于对照组的11.32%，但差异无统计学意义（?字2=0.483，P=0.486）。结论：十味龙胆花胶囊联合乙酰半胱氨酸胶囊治疗能有效减轻痰热壅肺型老年肺炎患者炎症反应，加快患者恢复，缩短住院时间，提升临床疗效，不良反应较少。 |
| 英文摘要: |
| Objective: To investigate the efficacy of shiweilongdanhua capsule combined with acetylcysteine capsule in the treatment of senile pneumonia of phlegm-heat obstructing lung syndrome and its effect on peripheral blood platelet-to-lymphocyte ratio (PLR) and neutrophil-to-lymphocyte ratio (NLR). Methods: A random number table method was used to divide 107 senile pneumonia in our hospital from January 2019 to October 2021 were selected, and divided into 54 cases in the observation group and 53 cases in the control group. The control group was treated with acetylcysteine capsule, and the observation group received the shiweilongdanhua capsule on this basis. Then the serum levels of C-reactive protein (CRP), interleukin 8 (IL-8) and interleukin 6 (IL-6), along with peripheral blood PLR and NLR were detected in both groups, thereafter, the clinical efficacy, adverse reaction rate, restoration of blood oxygen saturation, symptom regression time and hospital stay length were observed in both groups. Results: Levels of IL-8, IL-6, CRP, PLR and NLR yielded no statistical difference between the two groups at the baseline (P＞0.05). After 5 and 10 days of treatment, serum levels of five inflammation factors in the observation group were obvious lower than the control group (P＜0.05). The overall therapeutic efficacy rate was 96.30% in the observation group, which was obvious higher than the control group (84.91%) (?字2=4.096, P=0.043). The restoration of blood oxygen saturation, symptom regression time and hospital stay length in the observation group were obvious shorter than in the control group (P＜0.05). The adverse reaction rate was 7.40% in the observation group, which was slightly lower than 11.32% in the control group, with no statistical difference (?字2=0.483, P=0.486). Conclusion: Application of the shiweilongdanhua capsule combined with acetylcysteine capsule in the treatment of senile pneumonia of phlegm-heat obstructing lung syndrome can effectively reduce the adverse reaction rate, and promote the recovery, shorten the hospital stay length, improve clinical efficacy and ameliorate the inflammation reaction. |
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