| 李美萱,茅建春.系统性红斑狼疮合并代谢综合征相关性的Meta分析[J].实用中西医结合临床,2022,22(9): |
| 系统性红斑狼疮合并代谢综合征相关性的Meta分析 |
| Meta-analysis of the correlation between systemic lupus erythematosus and metabolic syndrome |
| 投稿时间：2022-05-22 修订日期：2022-06-17 |
| DOI： |
| 中文关键词: 系统性红斑狼疮 代谢综合征 危险因素 Meta分析 |
| 英文关键词: Systemic lupus erythematosus Metabolic syndrome Risk factors Meta analysis |
| 基金项目: |
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| 中文摘要: |
| 目的：通过Meta分析探索系统性红斑狼疮(SLE)和代谢综合征(MetS)的关系,系统回顾两者共患病(SLE-MetS)情况,探索SLE慢性病程疾病发展谱。方法：从中国知网、万方、维普、中国生物医学文献数据库、Pubmed、Embase、Cochrane library数据库中检索SLE和MetS相关中英文文献,制定标准进行文献管理和数据提取,最后进行统计学分析。结果：18篇文献纳入本次研究中,包含SLE患者6013例,SLE-MetS患者1830例。汇总SLE-MetS患病率为30.8%(95%CI 26.4%～35.2%)。肾炎(OR=3.53,95%CI 1.48～8.46)、损伤指数(SDI)(OR=1.83,95%CI 1.28～2.61)、身体质量指数(BMI)(OR=1.44,95%CI 1.02～2.03)、年龄(OR=1.05,95%CI 1.03～1.08)、羟氯喹(HCQ)(OR=0.30,95%CI 0.01～0.93)与SLE-MetS有显著关联。结论：本研究中,SLE-MetS合并患病率较高,合并患病的危险因素是肾炎、SDI越高、BMI越高、年龄越大,使用HCQ是保护因素。 |
| 英文摘要: |
| Objective: To systematically review the comorbidities of systemic lupus erythematosus (SLE) and metabolic syndrome (MetS) by meta-analysis, exploring the spectrum of chronic disease progression. Methods: SLE and MetS related literature in Chinese and English were retrieved from CNKI, Wanfang, VIP, CBM, Pubmed, Embase and Cochrane library databases, criteria were developed for literature management and data extraction, and finally statistical analysis was performed. Results: Eighteen literatures were included in this study, including 6013 SLE patients and 1830 SLE-MetS patients. The pooled prevalence of SLE-MetS was 30.8% (95%CI 26.4%~35.2%). Lupus nephritis (OR=3.53,95%CI 1.48~8.46), damage index (SDI) (OR=1.83,95%CI 1.28~2.61), body mass index (BMI) (OR=1.44,95%CI 1.02~2.03), age (OR=1.05,95%CI 1.03~1.08) and use hydroxychloroquine (HCQ) (OR=0.30,95%CI 0.01~0.93) were significantly associated with SLE-MetS. Conclusions: In this study, the prevalence of SLE-MetS is significant, and the risk factors are nephritis, higher SDI, higher BMI, and older age, and HCQ use is a protective factor. |
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