| 王卓.桂黄清热颗粒辅助治疗老年慢阻肺急性加重(痰热肺证)疗效观察及对血气分析指标的影响[J].实用中西医结合临床,2022,22(10): |
| 桂黄清热颗粒辅助治疗老年慢阻肺急性加重(痰热肺证)疗效观察及对血气分析指标的影响 |
| Clinical observation of Guihuang Qingre granules in adjuvant treatment of AECOPD (phlegm-heat lung syndrome) in the elderly and its influence on blood gas analysis indexes |
| 投稿时间：2022-04-15 修订日期：2022-05-10 |
| DOI： |
| 中文关键词: 桂黄清热颗粒 慢阻肺急性加重 疗效 血气分析 |
| 英文关键词: Guihuang Qingre Granule AECOPD curative effect blood gas analysis. |
| 基金项目: |
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| 中文摘要: |
| 目的 探讨桂黄清热颗粒辅助治疗老年慢阻肺急性加重（AECOPD）(痰热肺证)的临床疗效及对血气分析指标的影响。方法 按照随机数字表法将2019年2月至2022年2月我单位收治并确诊的80例老年AECOPD患者分入两组。对照组40例给予常规西药治疗，观察组40例上给予桂黄清热颗粒辅助常规西药治疗。采用肺功能仪检测两组老年慢阻肺急性加重患者治疗前后肺功能。采用全自动血气分析仪检测两组老年慢阻肺急性加重治疗前后血气分析指标。比较两组老年慢阻肺急性加重患者中医证候积分、临床疗效、肺功能、血气分析指标以及不良反应的发生情况。结果 两组患者治疗后咳嗽、咳痰、喘息的中医证候积分和总积分均下降，且与对照组相比观察组中医证候积分更低（P<0.05）。对照组临床总有效率明显低于观察组（72.50% vs 92.50%）（χ2=5.541，P=0.019）。两组老年慢阻肺急性加重患者治疗后FEV1、FVC、FEV1/FVC、PEF均升高，且观察组肺功能指标更高（P<0.05）。两组老年慢阻肺急性加重患者治疗后PCT、PaCO2均降低，且与对照组相比观察组PCT、PaCO2更低（P<0.05）；两组患者治疗后PaO2升高，且与对照组相比观察组PaO2更高（P<0.05）。对照组不良反应发生率明显高于观察组（17.50% vs 5.00%）（χ2=5.000，P=0.025）。结论 桂黄清热颗粒辅助治疗老年AECOPD患者，能够显著提高临床疗效，并且能够改善患者的肺功能和血气分析指标，且不良反应少，有临床推广应用的价值。 |
| 英文摘要: |
| Objective: To explore the clinical efficacy of Guihuang Qingre Granules in adjuvant treatment of elderly patients with AECOPD (phlegm-heat lung syndrome) and its effect on blood gas analysis indicators. Methods: By random number table method, 80 elderly AECOPD patients admitted and diagnosed in our unit from February 2019 to February 2022 were divided into two groups. The 40 cases in control group was given conventional western medicine treatment, and the observation group was given Guihuang Qingre Granules adjuvant therapy on the basis of the control group. The pulmonary function indicators of the two groups of patients before and after treatment were detected by spirometry. The automatic blood gas indexes were detected by automatic blood gas analyzer before and after treatment. The TCM syndrome scores, clinical efficacy, pulmonary function, blood gas analysis indexes and the occurrence of adverse reactions were compared in two groups. Results: After treatment, the TCM syndrome scores and total scores of cough, expectoration and wheezing in both groups decreased, and the TCM syndrome scores in the observation group were lower compared with control group(P<0.05). The total clinical effective rate in the control group was lower compared with observation group(72.50% vs 92.50%) (χ2=5.541, P=0.019). After treatment, FEV1, FVC, FEV1/FVC, and PEF in the two groups were all increased, and compared with control group, FEV1, FVC, FEV1/FVC, and PEF in the observation group were higher(P<0.05). After treatment, PCT and PaCO2 in both groups were decreased, and compared with control group, PCT and PaCO2 in observation group were lower(P<0.05). PaO2 in two groups increased after treatment, and compared with control group, PaO2 in observation group was higher(P<0.05). The incidence of adverse reactions in the control group was higher compared with observation group (17.50% vs 5.00%) (χ2=5.000, P=0.025). Conclusion: Guihuang Qingre Granules in the adjuvant treatment of elderly patients with AECOPD can significantly improve the clinical efficacy, and can improve the patient"s pulmonary function and blood gas analysis indicators, and has few adverse reactions, which has the value of clinical application. |
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