| 张鸿雁.十味龙胆花胶囊联合乙酰半胱氨酸胶囊治疗痰热壅肺型老年肺炎疗效观察及对外周血PLR与NLR水平的影响[J].实用中西医结合临床,2022,22(6): |
| 十味龙胆花胶囊联合乙酰半胱氨酸胶囊治疗痰热壅肺型老年肺炎疗效观察及对外周血PLR与NLR水平的影响 |
| Efficacy of Shiwei Longdanhua Capsule Combined with Acetylcysteine Capsule in the Treatment of Senile Pneumonia of Phlegm-heat Obstructing Lung Syndrome and Its Effect on Peripheral Blood PLR and NLR |
| 投稿时间：2022-03-28 修订日期：2022-04-12 |
| DOI： |
| 中文关键词: 十味龙胆花胶囊 乙酰半胱氨酸胶囊 痰热壅肺 老年肺炎 PLR NLR |
| 英文关键词: Shiwei Longdanhua Capsule Acetylcysteine capsule Phlegm-heat obstructing lung syndrome Senile pneumonia PLR NLR |
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| 中文摘要: |
| 目的探究十味龙胆花胶囊联合乙酰半胱氨酸在痰热壅肺型老年肺炎治疗中的疗效观察及对外周血PLR与NLR水平的影响。方法采用随机分组将我院2019年1月到2021年12月收治的107例老年肺炎病人分为观察组（n=54）与对照组（n=53），对照组采用乙酰半胱氨酸胶囊治疗，观察组在此基础上联合使用十味龙胆花胶囊治疗。治疗前后观察两组病人血清相关指标（IL-8、CRP、IL-6）的水平和外周血PLR、NLR的水平。观察两组病人的临床效果疗效、不良反应出现概率、血氧饱和度恢复时间、症状消退和住院时间。结果 IL-8、IL-6、CRP方面，两组病人治疗前 水平并无差异（P＞0.05）。治疗5、10d后 观察组IL-8、IL-6、CRP水平较对照组较对照组显著降低（P＜0.05）。治疗前两组病人 PLR、NLR水平无显著差异（P＞0.05）。治疗5、10d后 观察组PLR、NLR水平较对照组较对照组显著降低（P＜0.05）。观察组总有效率为96.30%显著高于对照组86.48%（χ2=4.096，P=0.043）。治疗后观察组血氧饱和度恢复、症状消退、住院所用时间均显著低于对照组（P＜0.05）。治疗后观察组总不良反应发生率为7.40%略低于对照组11.28%，但两组病人但两组病人不良反应发生率无显著差异（χ2=0.483，P=0.486）。结论十味龙胆花胶囊联合乙酰半胱氨酸胶囊治疗能有效降低病人不良反应发生率，加快病人恢复时间，减少住院时间，提升临床疗效率，降低病人炎性反应。 |
| 英文摘要: |
| Objective:To analyze the efficacy of Shiwei Longdanhua capsule combined with acetylcysteine capsule in the treatment of senile pneumonia of phlegm-heat obstructing lung syndrome and its effect on peripheral blood platelet-to-lymphocyte ratio (PLR) and neutrophil-to-lymphocyte ratio (NLR). Methods:One hundred and seven senile patients with pneumonia in our hospital from January 2019 to December 2021 were selected, and divided into 2 groups. Control group (n=53) received acetylcysteine capsule, based on this, observation group (n=54) received Shiwei Longdanhua capsule. Then the serum levels of C-reactive protein (CRP), interleukin 8 (IL-8) and interleukin 6 (IL-6), along with peripheral blood PLR and NLR were detected in both groups, thereafter, the clinical efficacy, adverse reaction rate, restoration of blood oxygen saturation, symptom regression time and hospital stay length were observed in both groups. Results：Levels of IL-6, IL-8 and CRP yielded no statistical difference between two groups at the baseline (P>0.05). After 5 and 10 days of treatment, serum levels of three inflammation factors in observation group were obvious lower than control group (P<0.05). Peripheral blood PLR and NLR denoted no statistical difference between two groups at the baseline (P>0.05), while the two indicators at post-treatment 5 and 10 d were significantly lower in observation group than in control group (P<0.05). The overall efficacy rate was 96.30% in observation group, which was obvious higher than control group(86.48% )(χ2=4.096, P=0.043). The restoration of blood oxygen saturation, symptom regression time and hospital stay length in observation group were obvious shorter than control group (P<0.05). The adverse reaction rate was 7.40% in observation group, which was slightly lower than 11.28% in control group, with no statistical difference (χ2=0.483, P=0.486). Conclusion: Application of Shiwei Longdanhua capsule combined with acetylcysteine capsule in the treatment of senile pneumonia of phlegm-heat obstructing lung syndrome can effectively reduce the adverse reaction rate, promote the recovery, shorten the hospital stay length and ameliorate the inflammation reaction. |
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