| [Abstract] Objective To explore the effect of gastric soup combined with omeprazole on serum cyclooxygenase-2 (COX-2) and gastrin (Gas) levels in patients with chronic superficial gastritis (CSG).Methods 88 CSG patients admitted to our hospital from September 2018 to August 2020 were divided into study group (n=44) and control group (n=44) according to random numbers method.The control group was on omeprazole, the study group combined with gastric soup on the above basis, and both groups were treated for 1 month.The clinical efficacy, TCM syndrome score, serum COX-2, Gas levels, inflammatory factors [interleukin-6 (IL-6) and tumor necrosis factor- (TNF-)] levels and adverse effects were compared.Results The total response rate study group was 95.45% (42 / 44), Higher than the control group, 75.00% (33 / 44), Statistically different (P <0.05); The points [(1.02 ± 0.21)], frequent belching [(1.05 ± 0.26)], noisy pantothenic acid [(0.98 ± 0.10)], bile reflux [(0.89 ± 0.08)] were lower than the control group [(2.53 ± 0.36), (2.49 ± 0.30), (1.98 ± 0.13), (1.65 ± 0.11)], Statistically different (P <0.05); COX-2 [(5.43 ± 0.76) IU / L] and Gas [(18.24 ± 3.16) ng/L] were lower than the control group [(9.87 ± 1.05) IU / L, (27.20 ± 2.87) ng/L], Statistically different (P <0.05); IL-6 levels [(17.31 ± 4.62) ng/L], TNF-levels [(19.51 ± 4.19) ng/L] were lower than the control group [(20.52 ± 4.81) ng/L, (25.57 ± 5.52) ng/L], Statistically different (P <0.05); The adverse R study group was 4.55% (2 / 44), Less than 18.18% (8 / 44) of the control group, Statistical difference (P <0.05).Conclusion Combined with omeprazole can help to improve various clinical symptoms, inhibit inflammatory response, reduce COX-2 and Gas levels, with few adverse effects, definite efficacy and high safety. |
