老年人群TPOAb、TGAb及TSH与骨代谢的相关性研究

陈霞霞; 林婷; 吕琦; 杨小玲; 冯敏

文章摘要

陈霞霞，林婷，吕琦，杨小玲，冯敏.老年人群TPOAb、TGAb及TSH与骨代谢的相关性研究[J].实用中西医结合临床,2021,21(20):6-7,143

老年人群TPOAb、TGAb及TSH与骨代谢的相关性研究

The Correlation Study Between TPOAb, TGAb, TSH and Bone Metabolism in the Elderly

DOI：

中文关键词: 甲状腺过氧化物酶抗体甲状腺球蛋白抗体促甲状腺激素骨代谢相关性

英文关键词: Thyroid peroxidase antibody Thyroglobulin antibody Thyroid stimulating hormone Bone metabolism Correlation

基金项目:福建省自然科学基金项目（编号：2019J01096）

作者	单位
陈霞霞，林婷，吕琦，杨小玲，冯敏	福建省老年医院内分泌科

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中文摘要:

目的：探讨甲状腺功能正常的老年人群甲状腺过氧化物酶抗体（TPOAb）、甲状腺球蛋白抗体（TGAb）、促甲状腺激素（TSH）与骨代谢的相关性。方法：回顾性分析2018年~2020年住院行甲状腺功能检查的老年患者205例为研究对象，根据骨密度检查结果分为骨量正常组（62例）、骨量异常组（143例），比较两组TPOAb、TGAb阳性率及TSH水平。根据TSH水平分为正常范围低TSH组和正常范围高TSH组，比较两组骨量异常的发生率，采用Logistic回归分析正常范围低水平TSH、TPOAb阳性、TGAb阳性与骨量异常的相关性。结果：骨量异常组TPOAb阳性率明显高于骨量正常组（P＜0.05）；骨量异常组与骨量正常组TGAb阳性率比较，无显著差异（P＞0.05）；骨量异常组TSH水平明显低于骨量正常组；正常范围低TSH组骨量异常发生率明显高于正常范围高TSH组（P＜0.05）。Logistic回归分析结果提示，正常范围低TSH水平、TPOAb阳性是骨量异常的独立危险因素。结论：正常范围低TSH水平、TPOAb可能影响老年人骨代谢，TGAb对骨代谢影响不大。

英文摘要:

Objective: To investigate the correlation between thyroid peroxidase antibody (TPOAb), thyroglobulin antibody (TGAb), thyroid stimulating hormone (TSH) and bone metabolism in elderly people with normal thyroid function. Methods: Retrospective analysis, 205 hospitalized elderly patients with thyroid function examination from 2018 to 2020 were selected as the research objects. According to the results of bone mineral density examination, were divided into normal bone mass group (62 cases) and abnormal bone mass group (143 cases). The positive rates of TPOAb, TGAb and the level of TSH were compared between the two groups. According to the level of TSH, were divided into normal range low TSH group and normal range high TSH group. The incidence of abnormal bone mass between the two groups was compared. The correlation between normal range low TSH, TPOAb positive, TGAb positive and abnormal bone mass was analyzed by Logistic regression. Results: The positive rate of TPOAb in abnormal bone mass group was significantly higher than that in normal bone mass group (P＜0.05); there was no significant difference in TGAb positive rate between abnormal bone mass group and normal bone mass group (P＞0.05); TSH level in abnormal bone mass group was significantly lower than that in normal bone mass group. The incidence of abnormal bone mass in normal range low TSH group was significantly higher than that in normal range high TSH group（P＜0.05）. Logistic regression analysis showed that normal range low TSH level and positive TPOAb were independent risk factors for abnormal bone mass. Conclusion: Normal range low TSH level and TPOAb may affect bone metabolism in the elderly, while TGAb has little effect on bone metabolism.

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