| 卢姗姗.不同剂量右美托咪定对颅脑外伤手术患者的镇静和脑保护效果分析[J].实用中西医结合临床,2021,21(17):107-109 |
| 不同剂量右美托咪定对颅脑外伤手术患者的镇静和脑保护效果分析 |
| Effect of Different Doses of Dexmedetomidine on Sedation and Brain Protection of Patients Undergoing Craniocerebral Trauma Surgery |
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| DOI： |
| 中文关键词: 颅脑外伤 右美托咪定 剂量选择 脑保护 镇静 |
| 英文关键词: dexmedetomidine dose selection traumatic brain injury brain protection sedation |
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| 中文摘要: |
| 目的：研究不同剂量右美托咪定对颅脑外伤手术患者镇静和脑保护效果分析。方法：选取2018年11月~2020年1月收治的颅脑外伤手术患者89例为研究对象，随机分为研究组44例与对照组45例，研究组右美托咪定静脉泵入量0.7 μg/kg，对照组泵入量1.0 μg/kg，比较两组泵入右美托咪定前与术毕时颈静脉血氧饱和度、动脉-颈内静脉含量血氧差（Da-jvO2）、脑氧摄取率（CERO2）、神经元特异性烯醇化酶（NSE）、S-100β水平及镇静评分（Ramsay）等指标。结果：T1时间点，研究组SjvO2水平高于对照组，Da-jvO2、CERO2水平均低于对照组，S-100β、NSE水平均明显优于对照组（P＜0.05）；术毕时和术后2 h，两组镇静评分比较均无显著性差异（P＞0.05）。结论：静脉泵入剂量0.7 μg/kg的右美托咪定对于颅脑外伤手术患者镇静效果更为显著，可以更好地保护患者大脑。 |
| 英文摘要: |
| Objective: To study the sedation and brain protective effects of different doses of dexmedetomidine on patients undergoing craniocerebral trauma surgery. Methods: 89 patients with craniocerebral trauma in our hospital from November 2018 to January 2020 were selected as the research objects and randomly divided into study group (44 cases) and control group (45 cases). The intravenous pump volume of study group was 0.7 μg/kg, while that of control group was 1.0 μg/kg. The two groups were compared in terms of jugular oxygen saturation, arterial-internal jugular oxygen content difference (Da-jvO2), cerebral oxygen uptake rate (CERO2), neuron-specific enolase (NSE), S-100β level and sedation score (Ramsay) before and after dexmedetomidine was pumped. Results: At T1 time point, the levels of SjvO2, Da-jvO2 and CERO2 in the study group were higher than those in the control group (P ＜ 0.05), and the levels of S-100β and NSE were significantly higher than those in the control group (P ＜0.05). There was no significant difference in sedation scores between the two groups at the end of operation and 2 hours after operation (P＞0.05). Conclusion: Intravenous dexmedetomidine (0.7 μg/kg) has a more significant sedative effect on patients undergoing craniocerebral trauma surgery, and can better protect patients’ brains. |
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