| 葛巍，范建先，杨苏琴，谢昌营.经内镜肠道植管术联合美沙拉秦灌肠治疗溃疡性结肠炎的应用研究[J].实用中西医结合临床,2021,21(17):6-8 |
| 经内镜肠道植管术联合美沙拉秦灌肠治疗溃疡性结肠炎的应用研究 |
| Application of Transendoscopic Enteral Tubing Combined with Mesalazine Enema in the Treatment of Ulcerative Colitis |
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| DOI： |
| 中文关键词: 溃疡性结肠炎 经内镜肠道植管术 美沙拉秦 保留灌肠 |
| 英文关键词: Ulcerative colitis Transendoscopic enteral tubing Mesalazine Retention enema |
| 基金项目:江西省卫生健康委科技计划项目（编号：20195530）；江西省中医药科技项目（编号：2019A281） |
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| 中文摘要: |
| 目的：观察经内镜肠道植管术（TET）联合美沙拉秦（5-ASA）灌肠治疗广泛结肠型轻中度溃疡性结肠炎（UC）的临床疗效及安全性。方法：选取2019年1月~2020年10月在江西中医药大学附属医院就诊的广泛结肠型轻中度UC患者58例，采用随机数字表法分为两组，最终观察组27例、对照组28例纳入研究。两组均给予相同剂量5-ASA治疗（口服+灌肠），观察组行TET联合5-ASA保留灌肠，对照组采用5-ASA灌肠液经肛保留灌肠，观察期为7 d。对比两组治疗前后改良Mayo评分，血沉（ESR）和C反应蛋白（CRP）水平，肠道保留时间、不良反应发生率及满意度。结果：治疗第7天，两组改良Mayo评分，ESR和CRP水平均较治疗前1 d明显降低（P＜0.05），且观察组改良Mayo评分，ESR和CRP水平改善均优于对照组（P＜0.05）。相比对照组，观察组肠道保留时间延长（P＜0.05）。结论：TET是提升广泛结肠型轻中度UC药物均疗效的有效措施，具有可行、安全、有效等特点。 |
| 英文摘要: |
| Objective: To observe the clinical efficacy and safety of transendoscopic enteral tubing (TET) combined with mesalazine (5-ASA) enema in the treatment of extensive colonic mild to moderate ulcerative colitis (UC). Methods: 58 Patients with extensive colonic mild to moderate UC treated in the affiliated hospital of Jiangxi university of traditional chinese medicine from January 2019 to October 2020 were divided into two groups according to the random number table method , 27 cases in the observation group and 28 cases in the control group were included studies. Both groups were given the same dose of 5-ASA (oral plus enema). The observation group was treated with TET combined with 5-ASA retention enema, and the control group was treated with 5-ASA enema solution anal retention enema. The observation period was 7 days. The modified Mayo score, erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) levels, intestinal retention time, incidence of adverse reactions and satisfaction were compared between the two groups before and after treatment. Results: After 7 days of treatment, the modified Mayo score, ESR and CRP levels of the two groups were significantly lower than those of the 1 day before treatment (P＜0.05), and the modified Mayo score, ESR and CRP levels in the observation group were better than those in the control group (P＜0.05). Compared with the control group, the intestinal retention time of the observation group was longer (P＜0.05). Conclusion: TET is an effective measure to improve the efficacy of extensive colonic mild to moderate UC drugs. It has the characteristics of feasibility, safety and effectiveness. |
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