| Objective: To investigate the risk factors of invasive pulmonary aspergillosis (IPA) in patients with chronic obstructive pulmonary disease (COPD). Methods: Case-control study on risk factors of IPA in patients with COPD were searched in databases such as Wanfang data, VIP, CNKI and PubMed, from creating database to March 2021. The RevMan 5.3 software was used for meta-analysis. Results: A total of 18 literatures were included, including 1 in English and 17 in Chinese, involving a total of 4,206 patients. Meta-analysis results showed a total of 13 risk factors, which were grade 3 or 4 COPD severity (OR=4.82, 95%CI: 1.38~16.84), serum albumin levels (MD=-7.70, 95%CI: -8.21~-7.19), hypoalbuminemia (OR=4.93, 95%CI: 3.04~7.99), combined diabetes (OR=6.78, 95%CI: 2.59~17.79), combined respiratory failure (OR=6.09, 95%CI: 3.19~11.63), combined with renal insufficiency (OR=2.97, 95%CI: 1.23~7.18), combined with cardiac insufficiency (OR=3.26, 95%CI: 1.38~7.68), long-term use of glucocorticoids (OR=3.96, 95%CI: 2.30~6.83), history of glucocorticoid use (OR=6.73, 95%CI: 3.34~13.56), duration of application of antibiotics (MD=8.25, 95%CI: 6.93~9.58), mechanical ventilation (OR=10.60, 95%CI: 6.18~18.15), invasive operation (OR=7.95, 95%CI: 3.74~16.92), ICU admission (OR=4.49, 95%CI: 3.02~6.67). Gender, smoking history, combined with liver dysfunction were not associated with COPD complicated with IPA. Conclusion: There are many risk factors for COPD patients complicated with IPA, and we need to identify the risk factors as soon as possible, which is of great significance for the prevention, treatment and prognosis of the disease. This study provides evidence-based reference for the prevention and diagnosis of COPD combined with IPA. |
