| 万阳，杨奕，刘慧莹，蔡恒斌，李金根，毛祥坤.半夏-陈皮“异病同治”咳嗽和冠心病的网络药理学作用机制研究[J].实用中西医结合临床,2021,21(14):1-5 |
| 半夏-陈皮“异病同治”咳嗽和冠心病的网络药理学作用机制研究 |
| Study on the Mechanism of Banxia-Chenpi in Treating Cough and Coronary Heart Disease with Concept of "Treating Different Diseases with the Same Treatment" Based on Network Pharmacology |
| |
| DOI： |
| 中文关键词: 咳嗽 冠心病 半夏-陈皮 网络药理学 异病同治 |
| 英文关键词: Cough Coronary heart disease Banxia-Chenpi Network pharmacology Treating different diseases with the same treatment |
| 基金项目:江西省卫健委中医药科研课题（编号：2018B012）；江西省卫健委科技计划（编号：202140156） |
|
| 摘要点击次数: 618 |
| 全文下载次数: 262 |
| 中文摘要: |
| 目的：通过网络药理学探讨中药药对半夏-陈皮治疗咳嗽、冠心病的分子机制，以探究该药对“异病同治”的共同作用机制。方法：从TCMSP、BATMAN-TCM数据库得出半夏-陈皮的活性成分及潜在靶标，从DisGeNET、OMIM、Drug Bank数据库得出与咳嗽、冠心病相关的疾病基因，并与半夏-陈皮潜在靶标进行映射，得出药对治疗两种疾病的共同靶标，将其输入String数据库及DAVID数据库，分别构建PPI网络、GO分析及KEGG PATHWAY分析。将半夏-陈皮治疗咳嗽、冠心病的活性成分及疾病基因输入Cytoscape软件，分别构建半夏-陈皮治疗咳嗽、冠心病的“重要活性成分-靶标”网络图。结果：半夏-陈皮治疗咳嗽的基因有49个、有效成分69个，治疗冠心病的基因有342个，有效成分87个，其中治疗两种疾病的交集靶标共有24个。构建PPI网络发现，交集靶标中排名前3的靶标蛋白为人白介素1B、肿瘤坏死因子、白细胞介素8。DAVID分析发现，治疗咳嗽的作用机制与TNF通路、T细胞受体信号通路、Toll样受体通路等25个通路相关。药对治疗冠心病的主要通路涉及HIF-1通路、TNF通路、AMPK通路等127个通路。“异病同治”的主要信号通路涉及NOD样受体信号通路、TNF通路、NF-κB通路、TGF-β通路等30个信号通路。结论：通过此次分析发现，半夏-陈皮药对“异病同治”的作用机制可能与NOD样受体信号通路、TNF通路、NF-κB通路、TGF-β通路等炎症通路相关。 |
| 英文摘要: |
| Objective: To explore the molecular mechanism of Banxia-Chenpi in the treatment of cough and coronary heart disease through network pharmacology, in order to explore the joint action mechanism of Banxia-Chenpi with concept of "treating different diseases with the same treatment". Methods: The active components and potential targets of Banxia-Chenpi were obtained from TCMSP and BATMAN-TCM databases, and the disease genes related to cough and coronary heart disease were obtained from DisGeNET, OMIM and Drug Bank databases. After mapping with potential targets of Banxia-Chenpi, the common targets for the treatment of the two diseases were obtained, which were input into String database and DAVID database to construct PPI network, GO analysis and KEGG PATHWAY analysis respectively. Finally, the active ingredients and disease genes of Banxia-Chenpi in treating cough and coronary heart disease were input into Cytoscape software, and the "important active ingredients target" network maps of Banxia-Chenpi in treating cough and coronary heart disease were constructed respectively. Results: There were 49 genes and 69 effective components in treating cough, 342 genes and 87 effective components in treating coronary heart disease. Among them, there were 24 overlapping targets in treating two diseases. The PPI network showed that the top three target proteins were human Interleukin-1B, tumor necrosis factor and interleukin-8. David analysis showed that the mechanism of cough treatment was related to TNF pathway, T cell receptor signaling pathway, Toll like receptor pathway and other 25 pathways. There are 127 pathways involved in the treatment of coronary heart disease, including HIF-1 pathway, TNF pathway and AMPK pathway, The main signaling pathways of "treating different diseases with the same treatment" involve NOD-like receptor signaling pathway, TNF pathway and NF-κB pathway, TGF- β signaling pathway these 30 signaling pathways. Conclusion: Through this analysis, we find that the mechanism of Banxia-Chenpi on "treating different diseases with the same treatment" may be related to NOD-like receptor signaling pathway, TNF pathway and NF-κB pathway, TGF- β pathway and other inflammatory pathways. |
|
查看全文
查看/发表评论 下载PDF阅读器 |
| 关闭 |
|
|
|
