| 陈杰.持续肾脏替代联合血必净治疗对脓毒症炎症介质和免疫指标影响的系统性分析[J].实用中西医结合临床,2021,21(13):1-4 |
| 持续肾脏替代联合血必净治疗对脓毒症炎症介质和免疫指标影响的系统性分析 |
| Systematic Analysis of the Efficacy of Continuous Renal Replacement Therapy Combined with Xuebijing on the Inflammatory Factors and Immune Indexes in Sepsis |
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| DOI： |
| 中文关键词: 脓毒症 血必净 连续性肾脏替代 随机对照试验 系统评价 Meta分析 |
| 英文关键词: Sepsis Xuebijing Continuous renal replacement therapy Randomized controlled trial System review Meta-analysis |
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| 中文摘要: |
| 目的：系统性分析持续肾脏替代联合血必净对脓毒症患者炎症反应和免疫功能的影响。方法：计算机检索PubMed、万方数据、CNKI、CENTRAL等电子数据库，查找持续肾脏替代联合血必净对脓毒症患者炎症反应和免疫功能影响的随机对照试验，检索时间均从建库~2019年6月。由两位研究者进行资料提取和质量评价后，采用RevMan 5.3软件进行Meta分析。结果：纳入5个RCT，共399例患者（血必净组为常规治疗加血必净治疗，共186例患者；连续性肾脏替代联合血必净组为常规治疗基础上血必净联合连续性肾脏替代治疗，共213例患者）。同血必净组相比，连续性肾脏替代联合血必净组可降低白细胞介素-6、肿瘤坏死因子-α、白细胞水平，同时升高CD4+水平，两组差异有统计学意义（P＜0.05）；而连续性肾脏替代联合血必净组CD3+水平同血必净组相比，差异无统计学意义（P=0.14）。结论：持续性肾脏替代联合血必净能有效改善脓毒症患者炎症反应，增强免疫功能。 |
| 英文摘要: |
| Objective: Systematic analysis of the effect of continuous renal replacement therapy combined with xuebijing on inflammatory response and immune function in patients with sepsis. Methods: The computer retrieved PubMed, Wanfang data, CNKI, CENTRAL and other electronic databases, and searched for the randomized controlled trial of the effects of continuous renal replacement therapy combined with xuebijing on inflammatory response and immune function of sepsis patients. The retrieval time was from the establishment of the database to June 2019. After the data extraction and quality evaluation were conducted by two researchers, the Meta-analysis was carried out by RevMan 5.3 software. Results: 5 RCTs involving 399 patients were included (186 patients in the xuebijing group, which xuebijing was used on the basis of routine treatment and 213 patients in the continuous renal replacement therapy combined with xuebijing group, which continuous renal replacement therapy combined with xuebijing was used on the basis of routine treatment). Compared with the xuebijing group, the continuous renal replacement therapy combined with xuebijing group could reduce the level of IL-6, TNF-α, WBC, and increase the level of CD4+, and difference between the two groups was statistically significant (P＜0.05). But there was no significant difference in the level of CD3+ between the two groups (P=0.14). Conclusion: Continuous renal replacement therapy combined with xuebijing can effectively improve the inflammatory response and enhance the immune function of patients with sepsis. |
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