| 陈光华，陈教华，吴云翔，彭迎迎，张磊昌，胡晓阳.少腹逐瘀汤加减治疗气亏血瘀型慢性放射性直肠炎的疗效观察[J].实用中西医结合临床,2021,21(10):7-10 |
| 少腹逐瘀汤加减治疗气亏血瘀型慢性放射性直肠炎的疗效观察 |
| Curative Effect of Chronic Radiation Proctitis with Qi Deficiency and Blood Stasis Type Treated by Modified Shaofuzhuyu Decoction* |
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| DOI： |
| 中文关键词: 慢性放射性直肠炎 气亏血瘀型 少腹逐瘀汤加减 TNF-α IL-6 |
| 英文关键词: Chronic radiation proctitis Qi deficiency and blood stasis type Modified Shaofuzhuyu decoction TNF-α IL-6 |
| 基金项目:江西省卫健委中医药科研项目（编号：2018A086） |
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| 中文摘要: |
| 目的：观察少腹逐瘀汤加减治疗气亏血瘀型慢性放射性直肠炎的疗效。方法：选取2019年1~12月肛肠科收治的气亏血瘀型慢性放射性直肠炎患者30例，按照平行对照随机单盲法操作，随机分为治疗组和对照组，各15例。治疗组采用少腹逐瘀汤加减保留灌肠治疗，对照组采用地塞米松+庆大霉素保留灌肠治疗。比较两组治疗2个疗程后的临床疗效，治疗前后中医症状积分，血清TNF-α、IL-6水平，半年内复发率。结果：治疗组临床疗效显著高于对照组（P＜0.05）；两组治疗后中医症状积分均较治疗前显著降低，且治疗组显著低于对照组（P＜0.05）；两组血清TNF-α、IL-6水平均较治疗前显著降低，且治疗组治疗后血清TNF-α、IL-6水平均低于对照组（P＜0.05）；随访半年，治疗组复发率低于对照组（P＜0.05）。结论：少腹逐瘀汤加减能够显著降低气亏血瘀型慢性放射性直肠炎患者的血清TNF-α、IL-6水平，改善患者中医症状，提高临床疗效，降低复发率。 |
| 英文摘要: |
| Objective: To observe the curative effect of chronic radiation proctitis with qi deficiency and blood stasis type treated by modified Shaofuzhuyu decoction. Methods: 30 Chronic radiation proctitis patients with qi deficiency and blood stasis type diagnosed in anorectal medicine from January 2019 to December 2019 were selected. According to the parallel control randomized single blind method, they were randomly divided into treatment group and control group, each with 15 cases. The treatment group was treated by retention enema with modified Shaofuzhuyu decoction, while the control group received retention enema with dexamethasone and gentamicin. Clinical efficacy, TCM symptom scores, serum TNF-α and IL-6 levels, and recurrence rate within half year of the two groups were recorded and compared after 2 period of treatments. Results: After treatment, the clinical efficacy of the treatment group was significantly higher than that of the control group (P＜0.05); the TCM symptom scores of the two groups after treatment were significantly reduced (P＜0.05), and the treatment group was significantly lower than that of the control group (P＜0.05); the levels of serum TNF-α and IL-6 of the two groups after treatment were significantly reduced (P＜0.05), and the levels of serum TNF-α and IL-6 in the treatment group were lower than that in the control group (P＜0.05). Follow up for half a year, the recurrence rate of the treatment group was lower than that in the control group (P＜0.05). There were no adverse reactions in the two groups during treatment and follow-up. Conclusion: Modified Shaofuzhuyu decoction can significantly reduce the levels of serum TNF-α and IL-6 in chronic radiation proctitis patients with qi deficiency and blood stasis type, improve the TCM symptoms, the clinical efficacy and reduce the recurrence rate. |
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