| 徐晖,朱素有,张思迪,姚亮亮.化痰活血通络法治疗急性缺血性中风病的疗效观察[J].实用中西医结合临床,2021,21(24): |
| 化痰活血通络法治疗急性缺血性中风病的疗效观察 |
| Therapeutic effect of resolving phlegm, activating blood circulation and dredging collaterals on acute ischemic stroke |
| 投稿时间：2021-09-30 修订日期：2021-11-09 |
| DOI： |
| 中文关键词: 急性缺血性中风病 化痰活血通络 SAA |
| 英文关键词: Acute ischemic stroke Resolving phlegm, activating blood circulation and dredging collaterals SAA |
| 基金项目:江西省卫生计生委中医药科研课题(编号:2018A006) |
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| 中文摘要: |
| 目的 观察中药化痰活血通络法对急性缺血性中风病的疗效及其对神经功能、血清SAA、CRP的影响。方法 选取2018年6月～2021年6月于江西中医药大学附属医院急诊科、脑病科和ICU住院的100例痰瘀阻络型急性缺血性中风病患者作为研究对象，采用随机数字表法将其分为试验组和对照组，每组50例。对组照采用常规治疗:吸氧、监测生命体征、控制体温、抗血小板聚集、调脂、神经保护等，试验组在对照组基础上联合化痰活血通络中药治疗，两组疗程均为14天。观察比较两组的临床疗效及治疗前后的神经功能缺损评分（NIHSS）、日常生活能力评分（BI指数）、血清淀粉样蛋白A（SAA）、C反应蛋白（CRP）以及不良反应发生情况。结果 试验组总有效率为92%，显著高于对照组的72%（P＜0.01）；治疗前两组NIHSS评分、BI指数及血清SAA、CRP比较均无显著差异（P＞0.05）；治疗后，两组NIHSS评分、血清SAA、CRP均显著下降，且试验组NIHSS评分及CRP显著低于对照组（P＜0.01），两组SAA比较无显著差异（P＞0.05）；治疗后两组BI指数较前均显著提高，试验组显著高于对照组（P＜0.01）；试验组不良反应发生率低于对照组，差异无统计学意义（P＞0.05）。结论 联合中药化痰活血通络法治疗痰瘀阻络型急性缺血性中风病可以获得更显著疗效，可以更大程度改善患者神经功能、提高日常生活能力及降低患者血清SAA、CRP水平，且临床安全性高，值得临床推广。 |
| 英文摘要: |
| Objective To observe the effect of traditional Chinese medicine on acute ischemic stroke and its effects on neurological function, serum SAA and CRP.Methods 100 patients with acute ischemic stroke of phlegm and blood stasis blocking collaterals hospitalized in the emergency department, encephalopathy department and ICU of the Affiliated Hospital of Jiangxi University of traditional Chinese medicine from June 2018 to June 2021 were selected as the research objects. They were randomly divided into experimental group and control group, with 50 cases in each group.Routine treatment for group photos: oxygen inhalation, monitoring vital signs, controlling body temperature, anti platelet aggregation, lipid regulation, neuroprotection, etc.The experimental group was treated with traditional Chinese medicine for resolving phlegm, activating blood circulation and dredging collaterals on the basis of the control group. The course of treatment of both groups was 14 days.The clinical efficacy, neurological deficit score (NIHSS), activity of daily living score (BI index), serum amyloid A (SAA), C-reactive protein (CRP) and adverse reactions were observed and compared between the two groups before and after treatment.Result The total effective rate in the experimental group was 92%, which was significantly higher than 72% in the control group (P<0.01). There was no significant difference in NIHSS score, Bi index, serum SAA and CRP between the two groups before treatment (P>0.05). After treatment, NIHSS score, serum SAA and CRP in the two groups decreased significantly, and NIHSS score and CRP in the experimental group were significantly lower than those in the control group (P<0.01). There was no significant difference in SAA between the two groups (P>0.05). After treatment, the Bi index of the two groups was significantly higher than that of the former, and the Bi index of the experimental group was significantly higher than that of the control group (P<0.01). The incidence of adverse reactions in the experimental group was lower than that in the control group, and the difference was not statistically significant (P>0.05).Conclusion The combination of traditional Chinese medicine resolving phlegm, activating blood circulation and dredging collaterals in the treatment of acute ischemic stroke with phlegm and blood stasis blocking collaterals can obtain more significant curative effect, improve patients" neurological function, improve the ability of daily living and reduce the levels of serum SAA and CRP. It has high clinical safety and is worthy of clinical promotion. |
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