| 唐晓玲 余涛 熊林楷 梁启军 余炅 王珠 熊墨年.益气清毒法对肺癌患者舌脉象动态演变干预的客观化研究[J].实用中西医结合临床,2021,21(9):1-4,138 |
| 益气清毒法对肺癌患者舌脉象动态演变干预的客观化研究 |
| Objective Study about Intervention of Yiqiqingdu Therapy Method on Dynamic Evolution of Tongue Image Characterizationsand Pulse Characterization in Patients with Lung Cancer |
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| DOI： |
| 中文关键词: 肺癌 益气清毒法 舌象 脉象 |
| 英文关键词: Lung%cancer %Yiqiqingdu%therapy%method %Tongue%image%characterization %Pulse%image%characterization |
| 基金项目:江西省卫生计划生育委员会中医药科研基金项目（编号：2015A082）；
国家中医药管理局第一批重点研究室 - 恶性肿瘤益气清毒重点研究室项目[编号：国中医药函（2009）95 号]；
国家中医药管理局—熊墨年全国名老中医药专家传承工作室项目[编号：国中医药人教发（2013）47 号] |
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| 中文摘要: |
| 目的：分析中晚期肺癌患者在中医益气清毒法干预后舌脉象客观化参数的动态演变，为中医临床客观化诊疗提供参
考。 方法：将 100 例中晚期肺癌患者随机分为治疗组和对照组各 50 例，治疗组给予中医益气清毒综合治疗，对照组给予西医治疗，
两组均治疗 4 个疗程，分别在治疗前、治疗 2 个疗程后及治疗 4 个疗程后各采集 1 次舌脉象参数，观察治疗过程中舌象和脉象参
数的变化。结果：（ 1 ）舌象变化：治疗组治疗 2 个疗程后与治疗前相比，润燥指数、厚薄指数、腐腻指数均有明显变化（ P ＜0.05 ）；治疗
4 个疗程后与治疗前相比，患者的润燥指数、裂纹指数、厚薄指数、腐腻指数具有明显变化（ P ＜0.05 ）；治疗 4 个疗程后与治疗 2 个
疗程后相比，裂纹指数和厚薄指数则有明显差异（ P ＜0.05 ）。对照组治疗 2 个疗程后和治疗 4 个疗程后与治疗前相比，润燥指数、裂
纹指数、腐腻指数均有明显变化（ P ＜0.05 ）；治疗 4 个疗程后与治疗 2 个疗程后相比，润燥指数下降和裂纹指数升高，均有显著差异
（ P ＜0.05 ）。治疗 2 个疗程后及治疗 4 个疗程后两组比较，润燥指数、厚薄指数、腐腻指数、裂纹指数均有明显差异（ P ＜0.05 ）。（ 2 ）脉
象变化：治疗组治疗 2 个疗程后及治疗 4 个疗程后与治疗前相比，患者的 h1 、 U 、 P 明显升高， h3/h1 明显降低，差异有统计学意义
（ P ＜0.05 ）；治疗 4 个疗程后与治疗 2 个疗程后比较， h1 、 U 、 h3/h1 变化有明显差异（ P ＜0.05 ）。 对照组治疗 2 个疗程后与治疗前相
比，患者的 h3/h1 明显降低，差异有统计学意义（ P ＜0.05 ）；治疗 4 个疗程后与治疗前相比，患者的 h1 、 U 、 P 明显升高， h3/h1 明显降
低，差异有统计学意义（ P ＜0.05 ）；治疗 4 个疗程后与治疗 2 个疗程后相比，患者的 U 升高，存在明显差异（ P ＜0.05 ）。治疗 2 个疗程
后，两组间 U 值有显著差异（ P ＜0.05 ），治疗组比对照组升高更明显；治疗 4 个疗程后，两组间 h1 、 U 、 h3/h1 有显著差异（ P ＜0.05 ），
治疗组 h1 、 U 值升高更明显， h3/h1 降低更明显，差异有统计学意义（ P ＜0.05 ）。 结论：通过舌脉象客观化研究，进一步证明了益气清
毒法能有效改善肺癌患者旳身体状况。 舌脉象参数可作为指导肺癌中医治疗的有效指标之一，但仍需进一步大样本的临床验证。 |
| 英文摘要: |
| Objective:%To%analyze%the%dynamic%evolution%of%objective%parameters%of%tongue%and%pulse%image%characterizations%in%
patients%with%advanced%lung%cancer%after%the%intervention%of%TCM%method%of%Yiqiqingdu%therapy%method,%so%as%to%provide%reference%for%the%
clinical%objective%diagnosis%and% treatment% of% Traditional% Chinese% Medicine.% Methods:% 100% patients% with% advanced% lung% cancer% were%
randomly%divided%into%treatment%group%and%control%group,%with%50%cases%in%each%group.%The%treatment%group%was%given%Traditional%Chinese%
Medicine%Yiqiqingdu%comprehensive%treatment,%and%the%control%group%was%given%western%medicine%treatment,%both%groups%were%treated%for%
4%courses.%Collected%the%parameters%of%tongue%and%pulse%image%characterizations%before%treatment,%after%2%courses%of%treatment%and%after%4%
courses%of%treatment%respectively,%and%observed%the%changes%of%tongue%and%pulse%image%characterization%parameters%during%the%treatment.%
Results:% (1)%Changes%of%tongue%image%characterization%parameters:%In%the%treatment%group,%after%2%courses%of%treatment%compared%with%
before%treatment,%the%Runzao%index,%Thickness%index%and%Greasy%coating%index%had%significant%changes% ( P ＜0.05);%after%4%courses%of%
treatment%compared%with%before%treatment,%the%Runzao%index,%Crack%index,%Thickness%index%and%Greasy%coating%index%had%significant%
changes% ( P ＜0.05);%after%4%courses%of%treatment%compared%with%after%2%courses%of%treatment,%the%Crack%index%and%Thickness%index%had%
significant%changes ( P ＜0.05).In%the%control%group,%compared%with%before%treatment,%the%Runzao%index,%Crack%index%and%Greasy%coating%
index%of%after%2%courses%and%after%4%courses%of%treatment%had%significant%changes% ( P ＜0.05);%after%4%courses%of%treatment compared%with%
after%2%courses%of%treatment,%the%Runzao%index%decreased%and%the%Crack%index%increased,%with%significant%differences% ( P ＜0.05).%After%2%
courses%of%treatment%and%after%4%courses%of%treatment,%there%were%significant%differences%in%Runzao%index,%Thickness%index,%Greasy%coating%
index%and%Crack%index%between%the%two%groups%( P ＜0.05).%(2)%Changes%of%pulse%image%characterization%parameters:%In%the%treatment%group,
After%2%courses%of%treatment%and%after%4%courses%of%treatment,%compared%with%before%treatment,%the%levels%of%h1,%U%and%P%were%significantly%increased,%and%the%ratio%of%h3/h1%was%significantly%decreased,%the%differences%were%statistically%significant%( P ＜0.05);%compared%with%before%
treatment,%the%levels%of%h1,%U%and%h3/h1%were%significantly%increased%( P ＜0.05);%after%4%courses%of%treatment %compared%with After%2%courses%
of%treatment,%%the%levels%of%h,%U%and%h3/h1%had%significant%differences. After%2%courses%of%treatment,%the%h3/h1% of% the% patients% was%
significantly%lower%than%before%treatment%the%differences%were%statistically%significant%( P ＜0.05);%after%4%courses%of%treatment,%the%h1,%U%and%P%
of%the%patients%were%significantly%higher%than%before%treatment,%and%the%h3/h1%was%significantly%lower%than%before%treatment%,%the%differences%
were%statistically%significant%( P ＜0.05);%after%4%courses%of%treatment,%the%U%of%the%patients%was%significantly%higher%than%after%2%courses%of%
treatment ( P ＜0.05).%After%2%courses%of%treatment,%there%was%a%significant%difference%in%U%value%between%the%two%groups% ( P ＜0.05),%and%the%
increase%of%U%value%in%the%treatment%group%was%more%obvious%than%that%in%the%control%group;%after%4%courses%of%treatment,%there%was%a%
significant%difference%in%h1,%U%and%h3/h1%between%the%two%groups% ( P ＜0.05),%and%the%increases%of%h1%and%U%value%in%the%treatment%group%
were%more%obvious,%and%the%decrease%of%h3/h1%was%more%obvious,%and%the%differences%were%statistically%significant% ( P ＜0.05).%Conclusion:%
Through% the% objective% study% of% tongue% and% pulse% image% characterizations,% it% is% further% proved% that% Yiqiqingdu% therapy% method% can%
effectively%improve%the%physical%condition%of%lung%cancer%patients.%Tongue%and%pulse%image%parameters%can%be%used%as%the%effective%
indicators%to%guide%the%treatment%of%lung%cancer%in%Traditional%Chinese%Medicine,%but%it%still%needs%further%large%sample%clinical%verification. |
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