| 朱杰,储岳峰.YKL-40、hs-CRP在老年冠心病患者中的临床意义[J].实用中西医结合临床,2021,21(15): |
| YKL-40、hs-CRP在老年冠心病患者中的临床意义 |
| To observe the clinical value of YKL-40、hs-CRP in elderly patients with coronary heart disease |
| 投稿时间：2021-05-26 修订日期：2021-06-07 |
| DOI： |
| 中文关键词: 冠心病 YKL-40 hs-CRP 老年 |
| 英文关键词: : coronary heart disease YKL-40 hs-CRP elderly |
| 基金项目:：1.安徽医科大学校科学研究基金资助项目,编号：2020xkj228；2.六安市人民医院科研课题项目,编号：2021kykt22。 |
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| 中文摘要: |
| 目的 观察分析甲壳质酶蛋白40(YKL-40)、高敏C反应蛋白(hs-CRP)在老年冠心病患者中的表达水平及临床意义。方法 选择2019年9月-2020年9月在六安市人民医院心内科就诊的老年患者75例,其中急性冠脉综合征(Acute Coronary Syndromes,ACS) 25例、稳定型心绞痛组(stable angina pectoris,SAP) 25例、对照组25例,测定各组人群血清中YKL-40、hs-CRP的表达量,通过方差分析比较各组之间表达差异、Pearson直线相关分析YKL-40、hs-CRP之前的相关性,logistic回归分析筛选冠心病分组中急性冠脉综合征及稳定型心绞痛的危险因素。结果 YKL-40、hs-CRP在ACS、SAP组血清中的表达量均明显高于对照组,与SAP组比较,YKL-40、hs-CRP在ACS组亦高于SAP组,差异有统计学差异(P <0.01)。同时,Pearson直线显示血清YKL-40与hs-CRP含量成正相关(r =0.756,P <0.01),二分类logistic回归分析结果显示,YKL-40、hs-CRP为冠心病的独立危险因素。结论 血清 YKL 40 、hs-CRP 对老年冠心病严重程度相关,临床上加强对其监测有利于预判病情。 |
| 英文摘要: |
| : Objective To observe and analyze the clinical value of YKL-40、hs-CRP in elderly patients with coronary heart disease. Methods 50 patients with coronary heart disease , including 25 cases of acuteScoronarySsyndrome (ACS), 25 cases of stable angina pectoris(SAP),in our hospital from Sep. 2019 to Sep. 2020, and 25 healthy controls were enrolled in the study. The serum levels of hs-CRP and YKL-40 were measured by ELISA, The basic data and biochemical index of the three groups was compared by varianceS analysis,Spearman correlation analysis was used to observe the correlation between YKL-40 and hs-CRP. Results The serum expression levels of YKL-40 and hs-CRP in ACS and SAP group were significantly higher than those in control group. Compared with SAP group, YKL-40 and hs-CRP in ACS group were also higher than those in SAP group. Meanwhile, The serum YKL-40 was positively correlated with hs-CRP content (r = 0.491, P <0.01). Conclusion Serum YKL 40 and hs CRP are related to the severity of coronary heart disease in the elderly. The combined detection of YKL 40 and hs CRP in serum could be used to predict clinical condition. |
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