| 王登本,李建英.非结核分支杆菌肺病与肺结核临床及影像学特征meta分析[J].实用中西医结合临床,2021,21(16): |
| 非结核分支杆菌肺病与肺结核临床及影像学特征meta分析 |
| Meta-analysis of clinical and imaging features of nontuberculous mycobacterial lung disease and tuberculosis |
| 投稿时间：2021-05-25 修订日期：2021-05-25 |
| DOI： |
| 中文关键词: 非结核分支杆菌肺病/NTM-PD 肺结核 CT影像学表现 meta分析 |
| 英文关键词: Nontuberculous mycobacterial lung disease tuberculosis CT imaging findings meta analysis |
| 基金项目:陕西省重点研发计划 |
|
| 摘要点击次数: 507 |
| 全文下载次数: 143 |
| 中文摘要: |
| 摘要：目的 探讨非结核分支杆菌（NTM）肺病与肺结核的影像学特征，并研究分析两者之间的差异。方法：应用计算机检索中国知网（CNKI）及万方医学网等数据库，查找建库到2020年12月的肺结核与非结核分支杆菌（NTM）肺病的病例对照文献，并进行meta分析。对照组为肺结核患者，实验组为非结核分支杆菌肺病患者，观察指征主要为临床表现和影像学表现。根据纳入/排除标准，对文献质量进行评价，并提取相应数据进行meta分析。结果：根据本研究的预定标准，最终纳入文献15篇，共包括2067例病人（非结核分支杆菌（NTM）肺病病人919例，肺结核病人1148例）。最终结果表明：与肺结核组相比，非结核分支杆菌（NTM）肺病组发热［OR（95%CI）：0.68（0.48～0.96）］发生率降低 ，咯血［OR（95%CI）：1.85（1.14～3.01）］发生率升高，咳嗽［OR（95%CI）：1.52（0.81～2.85）］发生率两者无统计学意义。与对照组肺结核相比，非结核分支杆菌（NTM）肺病组支气管扩张［OR（95%CI）：3.84（2.46～6.01）］、薄壁空洞［OR（95%CI）：1.61（1.08～2.40）］发生率升高，病变累及1-2个肺叶［OR（95%CI）：0.47（0.33～0.66）］、、淋巴结钙化［OR（95%CI）：0.30（0.20～0.43）］、淋巴结肿大［OR（95%CI）：0.44（0.25～0.77）］、厚壁空洞［OR（95%CI）：0.55（0.38～0.80）］发生率降低，病变累及5-6个肺叶［OR（95%CI）：1.42（0.66～3.04）］、病变累及3-4个肺叶［OR（95%CI）：0.73（0.50～1.05）］、胸膜增厚［OR（95%CI）：1.30（0.62～2.75）］发生率两者差异无统计学意义（P＞0.05）。结论：非结核分支杆菌（NTM）肺病的临床表现和影像学特征与肺结核类似，当临床研究上有针对上述临床特征及影像学特点且抗结核治疗效果表现不佳时应考虑到NTM肺病的可能。 |
| 英文摘要: |
| ABSTRACT: Objective: Explore the imaging characteristics of nontuberculous mycobacterial lung disease and tuberculosis, and analyze the differences between the two. Methods：Computer searches of databases such as China Knowledge Network (CNKI), VIP.com (VIP) and Wanfang Data Knowledge Service Platform, search for case-control research literature on non-tuberculous mycobacterial pulmonary disease and tuberculosis up to 2020 and conduct meta-analysis. The control group was pulmonary tuberculosis patients, and the observation group was non-tuberculous mycobacterial pulmonary disease patients. The observation indications were mainly imaging findings. Screen according to predetermined standards, evaluate the quality of the included studies, and extract corresponding indicators to complete the meta-analysis. Results：According to the predetermined criteria of this study, 15 articles were finally included, including 2067 patients (919 non-tuberculous mycobacterial (NTM) pulmonary disease patients and 1148 pulmonary tuberculosis patients). The final results showed that compared with the tuberculosis group, the incidence of fever [OR (95%CI): 0.68 (0.48～0.96)] in the nontuberculous mycobacterial (NTM) lung disease group was lower, and the incidence of hemoptysis [OR (95%CI): 1.85 ( 1.14～3.01)] The incidence of cough [OR (95%CI): 1.52 (0.81～2.85)] was not statistically significant. Compared with the control group of tuberculosis, the nontuberculous mycobacterial (NTM) lung disease group had bronchiectasis [OR (95%CI): 3.84 (2.46～6.01)] and thin-walled cavities [OR (95%CI): 1.61 (1.08～2.40) )] Incidence increased, lesions involved 1-2 lung lobes [OR (95%CI): 0.47 (0.33 ~ 0.66)], lymph node calcification [OR (95% CI): 0.30 (0.20 ~ 0.43)], lymph nodes Enlargement [OR (95%CI): 0.44 (0.25 ~ 0.77)], thick-walled cavities [OR (95% CI): 0.55 (0.38 ~ 0.80)] the incidence of reduced, lesions involving 5-6 lung lobes [OR ( 95%CI): 1.42 (0.66～3.04)], the lesion involves 3-4 lung lobes [OR (95%CI): 0.73 (0.50～1.05)], pleural thickening [OR (95%CI): 1.30 (0.62) ~2.75)] There was no statistically significant difference in incidence between the two (P>0.05).Conclusion：The clinical manifestations and imaging features of nontuberculous mycobacterial lung disease are similar to those of tuberculosis. When there are clinical features and imaging features as described above and the anti-tuberculosis treatment is not effective, the possibility of NTM lung disease should be considered. |
|
查看全文
查看/发表评论 下载PDF阅读器 |
| 关闭 |
|
|
|
